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SAB5200106

Sigma-Aldrich

Anti-SCNN1B antibody produced in rabbit

1 mg/mL, affinity isolated antibody

Synonym(s):

Anti-ENaC Beta, Anti-Scnn1b

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

mol wt

antigen predicted mol wt 87 kDa

species reactivity

mouse, human, rat

concentration

1 mg/mL

technique(s)

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

NCBI accession no.

NP_036780

UniProt accession no.

P51168

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

rat ... Scnn1b(24767)

General description

Sodium channel epithelial 1 β subunit (SCNN1B) is expressed in the posterior cerebral artery of rats. It is one of the subunits of epithelial sodium channels. The gene ID of the protein is 24767.

Specificity

Detects ~87 kDa.

Immunogen

AA617–638 of the rat sequence

Biochem/physiol Actions

Sodium channel epithelial 1 β subunit (SCNN1B) is involved in sodium transport in the epithelium.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

PBS, 50% glycerol, and 0.09% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Chengbiao Zhang et al.
American journal of physiology. Renal physiology, 312(4), F682-F688 (2017-04-04)
Mice transgenic for genomic segments harboring PHAII (pseudohypoaldosteronism type II) mutant Wnk4 (with-No-Lysine kinase 4) (TgWnk4PHAII) have hyperkalemia which is currently believed to be the result of high activity of Na-Cl cotransporter (NCC). This leads to decreasing Na+ delivery to
Lijun Wang et al.
Journal of the American Society of Nephrology : JASN, 26(11), 2678-2690 (2015-04-08)
Kcnj10 encodes the inwardly rectifying K(+) channel Kir4.1 in the basolateral membrane of the distal convoluted tubule (DCT) and is activated by c-Src. However, the regulation and function of this K(+) channel are incompletely characterized. Here, patch-clamp experiments in Kcnj10-transfected
Eok-Cheon Kim et al.
Experimental physiology, 97(4), 544-555 (2011-11-18)
It has been suggested that mechanosensitive ion channels initiate myogenic responses in vessels; however, the molecular identity of the mechanosensitive ion channel complex is unknown. Although previous reports have suggested that epithelial Na(+) channel (ENaC) proteins are mechanotransducers in arteries
Qiu-Shi Wang et al.
Frontiers in pharmacology, 12, 665111-665111 (2021-06-15)
The use of cyclosporine A (CsA) in transplant recipients is limited due to its side effects of causing severe hypertension. We have previously shown that CsA increases the activity of the epithelial sodium channel (ENaC) in cultured distal nephron cells.
Adverse effect of assisted reproductive technology-related hyperoestrogensim on the secretion and absorption of uterine fluid in superovulating mice during the peri-implantation period.
Xia, et al.
Frontiers in Endocrinology, 14, 859204-859204 (2023)
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