SAB4500839
Anti-FAP-1 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
PTP-BAS, PTP1E, PTPL1, PTPN13, α subunit, DPPIV, FAPA, SEPRASE, fibroblast activation protein
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About This Item
Recommended Products
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 87 kDa
species reactivity
human, mouse, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... FAP(2191)
Related Categories
General description
Fibroblast activation protein 1 (FAP-1) is a membrane-associated protein tyrosine phosphatase. It is made up of an ezrin-like cytoskeleton binding domain, six PSD95/Dlg/Z-1 homology (PDZ) domains, and a leucine zipper motif. The FAP-1 gene is located on the human chromosome at 4q21.3. Anti-FAP-1 antibody detects endogenous levels of total FAP-1 protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human FAP-1.
Immunogen Range: 331-380
Immunogen Range: 331-380
Application
Anti-FAP-1 antibody produced in rabbit has been used in western blotting (1: 500) and immunohistochemistry (10 μg/ml).
Biochem/physiol Actions
Fibroblast activation protein 1 (FAP-1) is involved in tumorigenesis, apoptosis, cancer progression, and insulin signaling. It acts as a prognostic marker in high-grade serous ovarian cancer and breast cancer. Overexpression of the FAP-1 gene is associated with several human cancers such as hepatocellular, pancreatic, ovarian, hematological, and colon cancer. Mutations in the FAP-1 gene lead to liver and lung cancer.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Protein tyrosine phosphatase-Basophil (PTP-Bas) is a membrane-associated protein tyrosine phosphatase with five PDZ domains and is involved in apoptosis, tumorigenesis, and insulin signaling. The interaction between PTP-Bas and tandem-PH-domain-containing protein 1/2 (TAPP1/2) plays an essential role in the regulation of
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