235135

Corticosterone

≥95% (HPLC), crystalline powder, corticosteroid hormone, Calbiochem

• Synonym(s): Corticosterone, (11β)-11,21-Dihydroxypregn-4-ene-3,20-dione, Reichstein’s substance H
• Empirical Formula (Hill Notation): C₂₁H₃₀O₄
• CAS Number: 50-22-6
• Molecular Weight: 346.46
• MDL number: MFCD00037715
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• product name: Corticosterone, Corticosteroid hormone synthesized in response to stress.
• Quality Level: 100
• Assay: ≥95% (HPLC)
• form: crystalline powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: off-white; white to tan
• solubility: ethanol: 50 mg/mL
• shipped in: ambient
• storage temp.: 10-30°C
• InChI: 1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
• InChI key: OMFXVFTZEKFJBZ-HJTSIMOOSA-N

Description

General description

Corticosteroid hormone synthesized in response to stress. Binds to and activates mineralocorticoid and glucocorticoid receptors, resulting in altered expression which eventually affects ionic conductances through the membrane. Also induces apoptosis in murine bone marrow.

Corticosteroid hormone synthesized in response to stress. Binds to and activates mineralocorticoid and glucocorticoid receptors, resulting in altered genomic expression. Steroid-induced changes in protein synthesis eventually affect ionic conductances through the membrane. Also induces apoptosis in murine bone marrow.

Biochem/physiol Actions

Cell permeable: no

Primary Target
Mineralocorticoid and glucocorticoid receptors

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Carcinogenic / Teratogenic (D)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Garvy, B.A., et al. 1993. Immunology80, 587.
DeKloet, E.R. 1992. Ann. N.Y. Acad. Sci.663, 357.
Joels, M., and deKloet, E.R. 1992. Trends Neurosci.15, 25.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3