860822P
Avanti
22:0(2S-OH) Ceramide
Avanti Research™ - A Croda Brand 860822P, powder
Synonym(s):
N-(2′-(S)-hydroxybehenoyl)-D-erythro-sphingosine
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
Recommended Products
form
powder
packaging
pkg of 1 × 5 mg (860822P-5mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 860822P
lipid type
sphingolipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC([C@@H](O)CCCCCCCCCCCCCCCCCCCC)=O)CO
General description
Ceramides containing 2-hydroxy fatty acids (hFA) are primarily found in the epidermis. 22:0(2S-OH) Ceramide is a 2S hydroxylated behenic acid-containing sphingolipid.
Biochem/physiol Actions
Sphingolipids containing hydroxy fatty acid (hFA) are implicated in cell signaling, cell differentiation and apoptosis. These lipids, which are found majorly in myelin sheath helps in formation and function of myelin. NAD(P)H-dependent enzyme, fatty acid 2-hydroxylase (FA2H) catalyzes the synthesis of hFA-ceramide. hFA-ceramides aid in epidermal permeability barrier function.
Packaging
5 mL Amber Glass Screw Cap Vial (860822P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Absence of 2-hydroxylated sphingolipids is compatible with normal neural development but causes late-onset axon and myelin sheath degeneration
The Journal of Neuroscience, 28(39), 9741-9754 (2008)
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(39), 9741-9754 (2008-09-26)
Sphingolipids containing 2-hydroxylated fatty acids are among the most abundant lipid components of the myelin sheath and therefore are thought to play an important role in formation and function of myelin. To prove this hypothesis, we generated mice lacking a
Normal fur development and sebum production depends on fatty acid 2-hydroxylase expression in sebaceous glands
The Journal of Biological Chemistry, 286(29), 25922-25934 (2011)
Stereospecificity of fatty acid 2-hydroxylase and differential functions of 2-hydroxy fatty acid enantiomers
Journal of Lipid Research, 53(7), 1327-1335 (2012)
The Journal of biological chemistry, 286(29), 25922-25934 (2011-06-02)
2-Hydroxylated fatty acid (HFA)-containing sphingolipids are abundant in mammalian skin and are believed to play a role in the formation of the epidermal barrier. Fatty acid 2-hydroxylase (FA2H), required for the synthesis of 2-hydroxylated sphingolipids in various organs, is highly
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service