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Sigma-Aldrich

Poly(ethylene glycol) methyl ether

average MN 20,000, methoxy, hydroxyl

Synonym(s):

Polyethylene glycol, Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, mPEG

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About This Item

Linear Formula:
CH3(OCH2CH2)nOH
CAS Number:
9004-74-4
MDL number:
MFCD00084416
UNSPSC Code:
12162002
NACRES:
NA.23

product name

Poly(ethylene glycol) methyl ether, average Mn 20,000

vapor density

>1 (vs air)

vapor pressure

0.05 mmHg ( 20 °C)

form

powder or crystals

mol wt

average Mn 20,000

mp

64-69 °C

Mw/Mn

≤1.2

Ω-end

hydroxyl

α-end

methoxy

storage temp.

−20°C

InChI

1S/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3

InChI key

XNWFRZJHXBZDAG-UHFFFAOYSA-N

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Application

  • Deoxycholic acid-grafted PEGylated chitosan micelles for the delivery of mitomycin C.: This study develops PEGylated chitosan micelles grafted with deoxycholic acid for effective delivery of mitomycin C, showcasing the potential of PEGylated compounds in pharmaceutical formulations and drug delivery systems (Zhang et al., 2015).

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

359.6 °F

Flash Point(C)

182 °C

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Biomaterials, 34(11), 2748-2757 (2013-01-25)
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Junming Li et al.
Journal of biomedical nanotechnology, 8(5), 809-817 (2012-08-15)
In this study, quercetin (QC) with cancer chemoprevention effect and anticancer potential was loaded into polymeric micelles of methoxy poly(ethylene glycol)-cholesterol conjugate (mPEG-Chol) in order to increase its water solubility. MPEG-Chol with lower critical micelle concentration (CMC) value (4.0 x
Seung-Young Lee et al.
Biomaterials, 34(2), 552-561 (2012-10-20)
Although targeted delivery mediated by ligand modified or tumor microenvironment sensitive nanocarriers has been extensively pursued for cancer chemotherapy, the efficiency is still limited by premature drug release after systemic administration. Herein we report a highly blood-stable, tumor-adaptable drug carrier
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International journal of pharmaceutics, 443(1-2), 175-182 (2013-01-05)
This work aims to develop curcumin (Cur) loaded biodegradable self-assembled polymeric micelles (Cur-M) to overcome poor water solubility of Cur and to meet the requirement of intravenous administration. Cur-M were prepared by solid dispersion method, which was simple and easy
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Articles

Degradable Poly(ethylene glycol) Hydrogels for 2D and 3D Cell Culture

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

Versatile Cell Culture Scaffolds: Bio-orthogonal Click

Designing biomaterial scaffolds mimicking complex living tissue structures is crucial for tissue engineering and regenerative medicine advancements.

Versatile Cell Culture Scaffolds: Bio-orthogonal Click

Designing biomaterial scaffolds mimicking complex living tissue structures is crucial for tissue engineering and regenerative medicine advancements.

Versatile Cell Culture Scaffolds: Bio-orthogonal Click

Designing biomaterial scaffolds mimicking complex living tissue structures is crucial for tissue engineering and regenerative medicine advancements.

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