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Key Documents

1091221

USP

Captopril disulfide

United States Pharmacopeia (USP) Reference Standard

Sinónimos:

1,1′-[Dithiobis[(2S)-2-methyl-1-oxo-3,1-propanediyl]]bis-L-proline

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About This Item

Fórmula empírica (notación de Hill):
C18H28N2O6S2
Número de CAS:
Peso molecular:
432.55
UNSPSC Code:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

captopril

manufacturer/tradename

USP

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

InChI

1S/C18H28N2O6S2/c1-11(15(21)19-7-3-5-13(19)17(23)24)9-27-28-10-12(2)16(22)20-8-4-6-14(20)18(25)26/h11-14H,3-10H2,1-2H3,(H,23,24)(H,25,26)/t11-,12?,13+,14+/m1/s1

Inchi Key

ZWKRXBCJAUKDCI-KRCVMZOZSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Captopril disulfide USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Captopril Tablets
  • Captopril
  • Captopril and Hydrochlorothiazide Tablets

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

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Waleed M M Mahmoud et al.
Chemosphere, 88(10), 1170-1177 (2012-04-27)
In some countries effluents from hospitals and households are directly emitted into open ditches without any further treatment and with very little dilution. Under such circumstances photo- and biodegradation in the environment can occur. However, these processes do not necessarily
Degradation of captopril in solutions compounded from tablets and standard powder.
D S Chan et al.
American journal of hospital pharmacy, 51(9), 1205-1207 (1994-05-01)
Takashi Nishikawa et al.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 20(10), 1395-1398 (2004-11-05)
Peculiarly shaped chromatograms of some compounds that consist of two reversible isomers have been reported. Those of a compound that consists of three reversible isomers are described here. Because disulfide of captopril has two cis-trans convertible bonds, it exists in
Captopril
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 733-733 (2021)
O H Drummer et al.
European journal of pharmacology, 153(1), 11-17 (1988-08-09)
The ability of captopril and one of its metabolites, the disulphide dimer have been studied for their ability to affect angiotensin I and bradykinin responses. Captopril disulphide dimer (i.v.) potentiated the vasodilatory effects of bradykinin in urethane-anaesthetized rats, at doses

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