PHL89180

Curcumin

phyproof^® Reference Substance

• Sinónimos: (E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, Diferuloylmethane, Diferulylmethane, Natural Yellow 3
• Fórmula lineal: [HOC₆H₃(OCH₃)CH=CHCO]₂CH₂
• Número de CAS: 458-37-7
• Peso molecular: 368.38
• Colour Index Number: 75300
• Beilstein/REAXYS Number: 2306965
• MDL number: MFCD00008365
• UNSPSC Code: 41116107
• NACRES: NA.24

Propiedades

• grade: primary reference standard
• vapor density: 13 (vs air)
• product line: phyproof^® Reference Substance
• assay: ≥98.0% (HPLC)
• form: powder
• manufacturer/tradename: PhytoLab
• SMILES string: COc1cc(\C=C\C(=O)CC(=O)\C=C\c2ccc(O)c(OC)c2)ccc1O
• InChI: 1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+
• InChI key: VFLDPWHFBUODDF-FCXRPNKRSA-N

Descripción

General description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biochem/physiol Actions

A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Curcumin has been cited as a potential chemopreventive agent, in addition to its chemotherapeutic activity. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.

Other Notes

This compound is commonly found in plants of the genus: curcuma

Legal Information

phyproof is a registered trademark of PhytoLab GmbH & Co. KG

Información de seguridad

• Storage Class: 13 - Non Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable