575608-U

Discovery^® DSC-Si 96-well solid phase extractio (SPE) Plate

bed wt. 50 mg/well, pk of 1

• Sinónimos: Silica SPE 96-well plate
• UNSPSC Code: 41104018
• NACRES: NB.21

Propiedades

• product name: Placa de 96 pocillos para SPE Discovery^® DSC-Si, bed wt. 50 mg/well, pk of 1
• material: PE frit (20 μm); polypropylene hardware
• Quality Level: 100
• composition: bed wt., 50 mg/well
• packaging: pk of 1
• technique(s): solid phase extraction (SPE): suitable
• surface area: 480 m²/g
• matrix: silica gel base material (irregularly shaped, acid washed)
• matrix active group: silica bonding
• particle size: 50 μm
• pore size: 70 Å pore size
• application(s): food and beverages
• separation technique: normal phase

Descripción

General description

Mecanismo de retención:: Fase normal
Compatibilidad de la matriz de la muestra: Disolventes orgánicos,

• Absorbente de sílice no ligada, lavada al ácido, ideal para EFS (SPE) y otras técnicas instantáneas modificadas
• Usado frecuentemente para separar o eliminar moléculas estructuralmente similares a través de eluciones sucesivas con soluciones cada vez más polares
• El absorbente de fase normal más polar de que se disponga
• Excelente capacidad para la purificación de la fase solución en reacciones de química combinatoria, cuando se separan las moléculas objeto del análisis de los subproductos de la reacción y del exceso de reactivos
• Disponible con configuraciones con embudo Büchner para facilitar la capacidad de ampliación

Application

• High-Throughput Mass Spectrometry for Biopharma: Utilizes the Discovery DSC-Si SPE 96-well plate for rapid and accurate biomolecule characterization, demonstrating its critical role in high-throughput analytical setups, enhancing productivity in biopharmaceutical analysis (Campuzano et al., 2022).


• Towards a Point-of-Care Diagnostic Platform for Multiplex Sensing: Highlights the application of Discovery DSC-Si SPE 96-well plates in developing advanced diagnostic platforms, specifically for detecting mild traumatic brain injury biomarkers, showcasing the plate′s versatility and reliability in clinical settings (Jović et al., 2022).


• Determination of Crizotinib in Plasma by LC-ESI-MS/MS: Demonstrates the use of Discovery DSC-Si SPE 96-well plates in pharmacokinetic studies, providing robust and efficient sample preparation methods for therapeutic drug monitoring and clinical research (Roberts et al., 2014).


• High-throughput Mass Spectrometric Cytochrome P450 Inhibition Screening: Applies the Discovery DSC-Si SPE 96-well plate in drug metabolism studies, specifically in the screening of cytochrome P450 enzyme inhibitors, which is crucial for predicting drug-drug interactions in drug development (Lim et al., 2013).


• Development of a High-Throughput SPE/MS Method for Cytochrome P450 Inhibition: Uses the Discovery DSC-Si SPE 96-well plate to enhance throughput in the pharmacological screening of drug candidates, underscoring its importance in the early stages of drug discovery to assess potential toxicities (Lim et al., 2010).

Legal Information

Discovery is a registered trademark of Merck KGaA, Darmstadt, Germany

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable