V7881
Monoclonal Anti-Vitronectin antibody produced in mouse
clone VIT-2, ascites fluid
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About This Item
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origen biológico
mouse
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
ascites fluid
tipo de anticuerpo
primary antibodies
clon
VIT-2, monoclonal
mol peso
antigen 65-75 kDa
contiene
15 mM sodium azide
reactividad de especies
human
técnicas
indirect ELISA: suitable
indirect immunofluorescence: suitable using human cultured fibroblasts
microarray: suitable
western blot: 1:2,500 using a denatured and reduced preparation of purified human plasma vitronectin
isotipo
IgM
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... VTN(7448)
Descripción general
Monoclonal Anti-Vitronectin (mouse IgM isotype) is derived from the VIT-2 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with purified human plasma vitronectin. Vitronectin is also referred as serum-spreading factor, S-protein of complement or epibolin. This monomeric acidic protein is one of the major multifunctional cell-adhesive glycoproteins in mammalian plasma and serum. This protein is usually seen as a mixture of 75 kDa and 65 kDa polypeptides. Human plasma and serum contain 0.1-0.4 mg/ml of vitronectin which is synthesized in the liver. It is also present in amniotic fluid and urine.
Especificidad
By immunoblotting, the product shows no cross-reactivity with fibronectin, laminin, merosin, collagen type IV or chondroitin sulfate types A, B and C.
Inmunógeno
human plasma vitronectin
Aplicación
Monoclonal Anti-Vitronectin antibody produced in mouse has been used in:
- immunocytochemisry
- western blotting
- immunoprecipitation
- immunofluorescence
- enzyme-linked immunosorbent assay (ELISA)
Acciones bioquímicas o fisiológicas
Vitronectin binds to heparin, collagen, streptococci and variety of cultured cells. It also acts as an inhibitor of the complement cascade by binding to the C5b-9 complex. Vitronectin protects thrombin from inactivation by antithrombin III in the presence of heparin, binds and stabilizes the activity of plasminogen activator inhibitor and mediates many other physiological functions.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
nwg
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Certificados de análisis (COA)
Lot/Batch Number
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
M Delannet et al.
Development (Cambridge, England), 120(9), 2687-2702 (1994-09-01)
To identify potentially important extracellular matrix adhesive molecules in neural crest cell migration, the possible role of vitronectin and its corresponding integrin receptors was examined in the adhesion and migration of avian neural crest cells in vitro. Adhesion and migration
S Cherian et al.
Neuropathology and applied neurobiology, 30(6), 585-600 (2004-11-16)
Posthaemorrhagic ventricular dilatation (PHVD) is a common complication of intraventricular haemorrhage in premature infants. The aim of this study was to investigate the role of transforming growth factor-betas (TGF-betas), a family of polypeptides with potent desmoplastic properties, in the aetiology
L Bello et al.
Neurosurgery, 49(2), 380-389 (2001-08-16)
This study analyzed the expression of integrins alpha(v)beta3 and alpha(v)beta5 in glioma tissue and focused on the periphery of high-grade gliomas. The analysis was performed with Western blot, immunohistochemistry, and immunofluorescence, by use of two monoclonal antibodies able to recognize
Novel purification of vitronectin from human plasma by heparin affinity chromatography
Yatohgo T, et al.
Cell Structure and Function, 13(4), 281-292 (1988)
Hepatocyte Growth Factor Regulates E Box-Dependent Plasminogen Activator Inhibitor Type 1 Gene Expression in HepG2 Liver Cells
Imagawa S, et al.
Arteriosclerosis, Thrombosis, and Vascular Biology (2006)
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
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