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V5765

Sigma-Aldrich

Vascular Endothelial Growth Factor 165 human

≥95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyophilized powder, suitable for cell culture

Sinónimos:

Vascular Endothelial Growth Factor 165

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About This Item

Código UNSPSC:
12352202
NACRES:
NA.77

Nombre del producto

VEGF165, recombinant, expressed in HEK 293 cells, suitable for cell culture

origen biológico

human

Nivel de calidad

200

recombinante

expressed in HEK 293 cells

descripción

Vascular Endothelial Growth Factor 165 human

Ensayo

≥95% (SDS-PAGE)

Formulario

lyophilized powder

potencia

<10 ng/mL ED50

calidad

endotoxin tested

mol peso

dimer 42 kDa (glycosylated)

envase

pkg of 10 μg
pkg of 50 μg

técnicas

cell culture | mammalian: suitable

impurezas

<0.075 EU/μg

color

white

solubilidad

water: soluble

Nº de acceso UniProt

P15692

temp. de almacenamiento

−20°C

Información sobre el gen

human ... VEGFA(7422)

Categorías relacionadas

Descripción general

VEGF165 is expressed in human HEK 293 cells as a glycosylated homodimer with an apparent molecular mass of 45 kDa. Production in human HEK 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.

Acciones bioquímicas o fisiológicas

VEGF165 belongs to the PDGF/VEGF growth factor family characterized by the presence of eight conserved cysteine residues and a cystine knot structure. VEGF is secreted by the majority of tumor cells and initiates angiogenesis by activating endothelial cells of existing blood vessels and promoting their migration.
VEGF has also been implicated in correlation with poor prognosis in breast cancer.
In addition, VEGF is released in rheumatoid arthritis in response to TNF-α, increasing endothelial permeability and stimulating angiogenesis (formation of capillaries).

Nota de análisis

The specific activity was determined by the dose-dependent stimulation of the proliferation of HUVEC cells (human umbilical vein endothelial cells).

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
0000233619
0000166601
0000166601
0000233619
049M4808V

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Lee M Ellis
Hematology/oncology clinics of North America, 18(5), 1007-1021 (2004-10-12)
This article focuses on the preclinical evidence for activation of the epidermal growth factor receptor (EGFR) in promoting angiogenesis and the efficacy of anti-EGFR agents in inhibiting angiogenesis and tumor growth.
Cheng Wang et al.
Nature communications, 12(1), 2616-2616 (2021-05-12)
FUN14 domain-containing protein 1 (FUNDC1) is an integral mitochondrial outer-membrane protein, and mediates the formation of mitochondria-associated endoplasmic reticulum membranes (MAMs). This study aims to determine the contributions of FUNDC1-mediated MAMs to angiogenesis in vitro and in vivo. In cultured
Xiaoqiang Tang
Cancer letters, 332(1), 3-10 (2013-01-26)
Breast cancer development largely depends upon the essential contributions from the tumor microenvironment, where several inflammatory cell populations (e.g. macrophages) orchestrate breast cancer development. The majority of tumor-associated macrophages (TAMs) exhibit alternatively activated M2 properties, produce abundant anti-inflammatory factors and
A O Afuwape et al.
Histology and histopathology, 17(3), 961-972 (2002-08-10)
The expansion of the synovial lining of joints in rheumatoid arthritis (RA), and the subsequent invasion by the pannus of underlying cartilage and bone, necessitates an increase in the vascular supply to the synovium, to cope with the increased requirement
C J Robinson et al.
Journal of cell science, 114(Pt 5), 853-865 (2001-02-22)
Vascular endothelial growth factor (VEGF) is a secreted mitogen highly specific for cultured endothelial cells. In vivo VEGF induces microvascular permeability and plays a central role in both angiogenesis and vasculogenesis. VEGF is a promising target for therapeutic intervention in
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VEGF Pathway

Read review on VEGF signaling pathway (Vascular endothelial growth factor (VEGF)/VEGF receptor) and find related products.

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