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Merck

U2625

Sigma-Aldrich

Ácido úrico

≥99%, crystalline

Sinónimos:

2,6,8-Trihidroxipurina

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About This Item

Fórmula empírica (notación de Hill):
C5H4N4O3
Número de CAS:
Peso molecular:
168.11
Beilstein/REAXYS Number:
156158
EC Number:
MDL number:
UNSPSC Code:
12352005
PubChem Substance ID:
NACRES:
NA.55
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Quality Level

100
200

assay

≥99%

form

crystalline

mp

>300 °C (lit.)

SMILES string

O=C1NC(=O)C2=C(N1)NC(=O)N2

InChI

1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)

InChI key

LEHOTFFKMJEONL-UHFFFAOYSA-N

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Application

El ácido úrico se ha utilizado:
  • para inducir hiperuricemia en ratones[1]
  • como componente del líquido de digestión para la simulación de un modelo de digestión humana in vitro[2]
  • en la prueba de selectividad del sensor de glucosa en el control de la diabetes por el sudor [3]

Biochem/physiol Actions

El ácido úrico es un catabolito insoluble producido por el metabolismo de la adenina y de la guanina. La acumulación de ácido úrico provoca gota, hiperuricemia, artritis e insuficiencia renal.[4] Niveles elevados de ácido úrico contribuyen a la hipertensión y a la patogenia de las enfermedades cardiovasculares.[5][6] Concentraciones bajas de ácido úrico asociadas con la enfermedad de Parkinson y la esclerosis múltiple pueden provocar una funcionalidad protectora.[6] Concentraciones elevadas de ácido úrico en pacientes con enfermedad pulmonar obstructiva crónica (EPOC) pueden servir como posibles marcadores para el diagnóstico.[7]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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Certificados de análisis (COA)

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Los clientes también vieron

Uric acid, hyperuricemia and vascular diseases
Jin M, et al.
Frontiers in Bioscience, 17, 656-656 (2012)
A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy
Lee H, et al.
Nature Nanotechnology, 11(6), 566-566 (2016)
Reduction of Serum Uric Acid Associated with Attenuation of Renal Injury, Inflammation and Macrophages M1/M2 Ratio in Hyperuricemic Mice Model
HARYONO A, et al.
Kobe J. Med. Sci., 64(3), E107-E114 (2018)
Serum uric acid: a risk factor and a target for treatment?
Feig DI, et al.
Journal of the American Society of Nephrology, 17(4), S69-S73 (2006)
Uric acid in plants and microorganisms: Biological applications and genetics-A review
Hafez RM, et al.
Journal of Advanced Research, 8(5), 475-486 (2017)

Artículos

Uric acid present in animal sera impacts serum-supplemented classical cell culture systems, influencing cell culture performance.

Uric acid present in animal sera impacts serum-supplemented classical cell culture systems, influencing cell culture performance.

Uric acid present in animal sera impacts serum-supplemented classical cell culture systems, influencing cell culture performance.

Uric acid present in animal sera impacts serum-supplemented classical cell culture systems, influencing cell culture performance.

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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