SRP0179
Lysyl Oxidase-like 2 (LOXL2) FLAG-tag (Sf9-derived) human
recombinant, expressed in baculovirus infected insect cells, ≥65% (SDS-PAGE)
Sinónimos:
LOR2, LOXL2, WS9-14
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About This Item
Código UNSPSC:
12352204
NACRES:
NA.32
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origen biológico
human
recombinante
expressed in baculovirus infected insect cells
Ensayo
≥65% (SDS-PAGE)
Formulario
aqueous solution
envase
pkg of 10 μg
concentración
>0.02 mg/mL
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
dry ice
temp. de almacenamiento
−70°C
Información sobre el gen
human ... LOXL2(4017)
Descripción general
The gene LOXL2 (lysyl oxidase like 2) is mapped to human chromosome 8p21.3. It is widely expressed and belongs to the LOX family of proteins. The protein has a conserved C-terminus region with catalytic function and a divergent N-terminal part.
Human LOXL2 (GenBank Accession No. NM_002318), amino acids 500-end, MW = 32kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Human LOXL2 (GenBank Accession No. NM_002318), amino acids 500-end, MW = 32kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Aplicación
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Acciones bioquímicas o fisiológicas
LOXL2 (lysyl oxidase like 2) is an amino oxidase which is dependent on copper and quinone. LOXL2 participates in various events, such as gene transcription, cell migration, adhesion, angiogenesis and differentiation. It is responsible for connecting collagen and/or elastin in the extracellular matrix. It deaminates trimethylated lysine 4 in histone H3, causing transcriptional repression. LOXL2 also oxidises methylated TAF10 (TATA-box binding protein associated factor 10), suppressing some TFIID (transcription factor IID)-associated genes. The LOXL2 gene is upregulated in various cancers, such as gastric cancer, breast cancer and squamous cell carcinomas. The gene is associated with cancer cell invasion, lymph node metastasis and poor overall patient survival.
Forma física
Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 20% glycerol and 3 mM DTT
Nota de preparación
Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.
Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Certificados de análisis (COA)
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
The function and mechanisms of action of LOXL2 in cancer (Review).
Wu L and Zhu Y
International Journal of Molecular Medicine, 36, 1200-1204 (2015)
The LOXL2 gene encodes a new lysyl oxidase-like protein and is expressed at high levels in reproductive tissues.
Jourdan-Le Saux C, et al.
The Journal of Biological Chemistry, 274, 12939-12944 (1999)
LOXL2 Oxidizes Methylated TAF10 and Controls TFIID-Dependent Genes during Neural Progenitor Differentiation.
Iturbide A, et al.
Molecular Cell, 58, 755-766 (2015)
Keiko Mizuno et al.
International journal of oncology, 48(2), 450-460 (2015-12-18)
Lung cancer remains the most frequent cause of cancer-related death in developed countries. A recent molecular-targeted strategy has contributed to improvement of the remarkable effect of adenocarcinoma of the lung. However, such treatment has not been developed for squamous cell
Rika Nishikawa et al.
FEBS letters, 589(16), 2136-2145 (2015-06-23)
Here, we found that members of the microRNA-29 family (miR-29a/b/c; "miR-29s") were significantly reduced in clear cell renal cell carcinoma (ccRCC) tissues, suggesting that they functioned as tumour suppressors. Restoration of all mature members of the miR-29 family inhibited cancer
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