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Key Documents

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SML2054

Sigma-Aldrich

SEA0400

≥98% (HPLC)

Sinónimos:

SEA0400, 2-[4-[(2,5-Difluorophenyl)methoxy]phenoxy]-5-ethoxybenzenamine, SEA 0400

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About This Item

Fórmula empírica (notación de Hill):
C21H19F2NO3
Número de CAS:
223104-29-8
Peso molecular:
371.38
MDL number:
MFCD07772188
UNSPSC Code:
12352200
NACRES:
NA.77

assay

≥98% (HPLC)

form

powder

color

white to beige

shipped in

ambient

storage temp.

−20°C

SMILES string

CCOC1=CC=C(OC2=CC=C(OCC3=C(F)C=CC(F)=C3)C=C2)C(N)=C1

InChI

1S/C21H19F2NO3/c1-2-25-18-8-10-21(20(24)12-18)27-17-6-4-16(5-7-17)26-13-14-11-15(22)3-9-19(14)23/h3-12H,2,13,24H2,1H3

InChI key

YSUBLPUJDOWYDP-UHFFFAOYSA-N

Biochem/physiol Actions

SEA0400 is a potent and selective inhibitor of Na+/Ca2+exchanger (NCX). SEA0400 potently inhibits Na+/Ca2+ exchanger activity in rat astrocytes, microglia, cultured neurons, and rat cardiomyocytes.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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T Matsuda et al.
The Journal of pharmacology and experimental therapeutics, 298(1), 249-256 (2001-06-16)
The effect of the newly synthesized compound 2-[4-[(2,5-difluorophenyl)methoxy]phenoxy]-5-ethoxyaniline (SEA0400) on the Na+-Ca2+ exchanger (NCX) was investigated and compared against that of 2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea (KB-R7943). In addition, the effects of SEA0400 on reperfusion injury in vitro and in vivo were examined. SEA0400
Torsten Christ et al.
European journal of pharmacology, 788, 286-293 (2016-07-05)
The Na(+)/Ca(2+) exchanger (NCX) plays a major role in myocardial Ca(2+) homoeostasis, but is also considered to contribute to the electrical instability and contractile dysfunction in chronic atrial fibrillation (AF). Here we have investigated the effects of the selective NCX
Kanna Yamashita et al.
Naunyn-Schmiedeberg's archives of pharmacology, 389(11), 1205-1214 (2016-08-03)
Recently, YM-244769 (N-(3-aminobenzyl)-6-{4-[(3-fluorobenzyl)oxy]phenoxy} nicotinamide) has been reported as a new potent and selective Na+/Ca2+ exchange (NCX) inhibitor by using various cells transfected with NCX using the 45Ca2+ fluorescent technique. However, the electrophysiological study of YM-244769 on NCX had not been

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