SML1578

Aftin-4

≥98% (HPLC)

• Sinónimos: (2R)-2-[[9-(1-Methylethyl)-6-[methyl(phenylmethyl)amino]-9H-purin-2-yl]amino]-1-butanol, Amyloid-β Forty-Two Inducer 4, N6-Methyl-(R)-roscovitine
• Fórmula empírica (notación de Hill): C₂₀H₂₈N₆O
• Número de CAS: 866893-90-5
• Peso molecular: 368.48
• UNSPSC Code: 12352200
• NACRES: NA.77

Propiedades

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: powder
• storage condition: protect from light
• color: white to beige
• solubility: DMSO: 25 mg/mL, clear
• storage temp.: −20°C

Descripción

Biochem/physiol Actions

Aftin-4, an amyloid forty-two inducer, activates γ-secretase, promoting the generation of amyloid-β-1-42 (Aβ1-42) from amyloid-β protein precursor. Aftin-4 increased Aβ-1-42, but not Aβ-1-40 in mouse hipppocampus, accompanied by learning deficits and mitochondrial ultrastructural changes similar to those found in the brains of patients with AD. Aftin-4 can thus be used to induce a rapid, acute Alzheimer′s disease-like toxicity in the rodent brain.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3