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SML1124

CPCCOEt

Name: CPCCOEt
Brand: SIGMA

≥98% (HPLC)

Sinónimos:

7-Hydroxyiminocyclopropan[b]chromen-1α-carboxylic acid ethyl ester

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About This Item

Fórmula empírica (notación de Hill):

C₁₃H₁₃NO₄

Número de CAS:

179067-99-3

Peso molecular:

247.25

MDL number:

MFCD00947859

UNSPSC Code:

12352200

PubChem Substance ID:

329825663

NACRES:

NA.77

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H1377

4-Hydroxy-3-methoxyphenylglycol hemipiperazinium salt

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M5435

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Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

DMSO: 20 mg/mL, clear

storage temp.

2-8°C

SMILES string

O=C(OCC)C(C1)(OC2=C/3C=CC=C2)C1C3=N/O

InChI

1S/C13H13NO4/c1-2-17-12(15)13-7-9(13)11(14-16)8-5-3-4-6-10(8)18-13/h3-6,9,16H,2,7H2,1H3/b14-11-

InChI key

FXCTZFMSAHZQTR-KAMYIIQDSA-N

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Biochem/physiol Actions

CPCCOEt is a selective non-competitive metabotropic glutamate receptor mGluR1 antagonist with no agonist or antagonist activity at mGlu2, 4a, 5a, 7b, 8a or ionotropic receptors at concentrations of up to 100 μM.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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The Role of Metabotropic Glutamate Receptor 1 Dependent Signaling in Glioma Viability.

Carrie Bowman Dalley et al.

The Journal of pharmacology and experimental therapeutics, 367(1), 59-70 (2018-07-29)

Glioma refers to malignant central nervous system tumors that have histologic characteristics in common with glial cells. The most prevalent type, glioblastoma multiforme, is associated with a poor prognosis and few treatment options. On the basis of reports of aberrant

Inhibition of metabotropic glutamate receptor 5 facilitates hypoxia-induced glioma cell death.

Bo Liu et al.

Brain research, 1704, 241-248 (2018-10-23)

Glioma is a primary brain tumor with high frequency and dismal prognosis. As there is no permanent cure available, identifying new therapy or mediator to augment the effectiveness of existing therapy is urgently needed. In the current study we tested

Local Estrogen Synthesis Regulates Parallel Fiber-Purkinje Cell Neurotransmission Within the Cerebellar Cortex.

Valerie L Hedges et al.

Endocrinology, 159(3), 1328-1338 (2018-01-31)

Estrogens affect cerebellar activity and cerebellum-based behaviors. Within the adult rodent cerebellum, the best-characterized action of estradiol is to enhance glutamatergic signaling. However, the mechanisms by which estradiol promotes glutamatergic neurotransmission remain unknown. Within the mouse cerebellum, we found that

Glutamate Attenuates the Survival Property of IGFR through NR2B Containing N-Methyl-D-aspartate Receptors in Cortical Neurons.

Xia Zhao et al.

Oxidative medicine and cellular longevity, 2020, 5173184-5173184 (2020-08-28)

Glutamate-induced neurotoxicity is involved in various neuronal diseases, such as Alzheimer's disease. We have previously reported that glutamate attenuated the survival signaling of insulin-like growth factor-1 (IGF-1) by N-methyl-D-aspartate receptors (NMDARs) in cultured cortical neurons, which is viewed as a

Cerebellar modulation of synaptic input to freezing-related neurons in the periaqueductal gray.

Christopher E Vaaga et al.

eLife, 9 (2020-03-25)

Innate defensive behaviors, such as freezing, are adaptive for avoiding predation. Freezing-related midbrain regions project to the cerebellum, which is known to regulate rapid sensorimotor integration, raising the question of cerebellar contributions to freezing. Here, we find that neurons of

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Key Documents

CPCCOEt

≥98% (HPLC)

About This Item

Productos recomendados

Propiedades

Quality Level

assay

form

storage condition

color

solubility

storage temp.

SMILES string

InChI

InChI key

Descripción

Biochem/physiol Actions

Features and Benefits

Información de seguridad

Storage Class

wgk_germany

flash_point_f

flash_point_c

Documentación

Certificados de análisis (COA)

¿Ya tiene este producto?

Artículos con revisión científica externa.

Protocolos y artículos

Artículos

Servicio técnico