SML0886

Leukadherin-1

≥98% (HPLC)

• Sinónimos: 4-[5-[[4-Oxo-3-(phenylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]-2-furanyl]-benzoic acid, LA1, Leukadhedrin 1, Leukadherin 1
• Fórmula empírica (notación de Hill): C₂₂H₁₅NO₄S₂
• Número de CAS: 344897-95-6
• Peso molecular: 421.49
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: , yellow to orange to brown
• solubilidad: DMSO: 3 mg/mL, clear (warmed)
• temp. de almacenamiento: 2-8°C
• cadena SMILES: S1\C(=C/c3[o]c(cc3)c4ccc(cc4)C(=O)O)\C(=O)N(C1=S)Cc2ccccc2
• InChI: 1S/C22H15NO4S2/c24-20-19(29-22(28)23(20)13-14-4-2-1-3-5-14)12-17-10-11-18(27-17)15-6-8-16(9-7-15)21(25)26/h1-12H,13H2,(H,25,26)/b19-12-
• Clave InChI: AEZGRQSLKVNPCI-UNOMPAQXSA-N

Descripción

Acciones bioquímicas o fisiológicas

Leukadherin-1 is an agonist of complement receptor-3 (CR3) and exhibits anti-inflammatory activity. It is an allosteric agonist that activates integrin by binding to a different site from the ligand binding. Leukadherin-1 plays an important role in the margination and adhesion of neutrophils to the endothelial lining of the blood vessels.

Leukadherin-1 is an agonist of integrin CD11b/CD18

Leukadherin-1 is an agonist of integrin CD11b/CD18 that can increase the extent of CD11b/CD18-dependent cell adhesion of transfected cells and of primary human and mouse neutrophils. Also, Leukadherin-1 decreases leukocyte recruitment and reduced arterial narrowing after injury in rats.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable