SAB4502906
Anti-Synaptophysin antibody produced in rabbit
affinity isolated antibody
Sinónimos:
major synaptic vesicle protein p38, synaptophysin
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About This Item
Productos recomendados
origen biológico
rabbit
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
affinity isolated antibody
tipo de anticuerpo
primary antibodies
clon
polyclonal
Formulario
buffered aqueous solution
mol peso
antigen 33 kDa
reactividad de especies
mouse, rat, human
concentración
~1 mg/mL
técnicas
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... SYP(6855)
Descripción general
Synaptophysin (SYP) is an integral membrane protein of synaptic vesicles. It is expressed in cortical synaptic terminals, during neurogenesis. The gene is located on human chromosome Xp11.23.
Synaptophysin is an integral membrane glycoprotein that is localized in presynaptic vesicles of nerve cells. This protein may regulate exocytosis and the formation of synaptic vesicles . Synaptophysin is encoded by the SYP gene and genetic alterations in SYP can lead to mental retardation . Anti-synaptophysin antibody specifically detects endogenous levels of total synaptophysin protein.
Inmunógeno
The antiserum was produced against synthesized peptide derived from human Synaptophysin.
Immunogen Range: 101-150
Immunogen Range: 101-150
Aplicación
Anti-Synaptophysin antibody produced in rabbit has been used in:
- immunocytochemistry
- western blotting
- immunohistochemistry
Anti-synaptophysin antibody is suitable for use in immunohistochemistry and western blot.
Acciones bioquímicas o fisiológicas
Synaptophysin (SYP) modulates neurotransmitter release and synaptic plasticity. It maintains biogenesis and recycling of synaptic vesicles. SYP functions as a marker for neuroendocrine tumors. It is used as a potent marker for neuroendocrine prostate cancer (NEPC). Mutations in this gene is associated with X-linked intellectual disability.
Características y beneficios
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Forma física
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Opcional
Referencia del producto
Descripción
Precios
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
nwg
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Single cell transcriptome analysis of mouse carotid body glomus cells
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The Journal of Physiology, 594(15), 4225-4251 (2016)
X-linked intellectual disability-associated mutations in synaptophysin disrupt synaptobrevin II retrieval
Gordon SL and Cousin MA
The Journal of Neuroscience, 33(34), 13695-13700 (2013)
Sarah Plum et al.
Cells, 9(12) (2020-12-06)
The pathological hallmark of Parkinson's disease (PD) is the loss of neuromelanin-containing dopaminergic neurons within the substantia nigra pars compacta (SNpc). Additionally, numerous studies indicate an altered synaptic function during disease progression. To gain new insights into the molecular processes
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