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SAB4500248

Sigma-Aldrich

Anti-DJ-1 antibody produced in rabbit

affinity isolated antibody

Sinónimos:

Oncogene DJ1, PARK7, Parkinson disease protein 7, Protein DJ-1

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

Formulario

buffered aqueous solution

mol peso

antigen 19 kDa

reactividad de especies

mouse, human

concentración

~1 mg/mL

técnicas

ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Nº de acceso NCBI

Q99497

Nº de acceso UniProt

Q99497

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... PARK7(11315)

Categorías relacionadas

Descripción general

Anti-DJ-1 Antibody detects endogenous levels of total DJ-1 protein.
DJ-1 (protein deglycase)/PARK7 (parkinsonism associated deglycase) is an oncogene, made of 189 amino acids. It is present in several human tissues and is located on chromosome 1p36.

Inmunógeno

The antiserum was produced against synthesized peptide derived from human DJ-1.

Immunogen Range: 21-70

Aplicación

Anti-DJ-1 antibody has been used in western blotting.

Acciones bioquímicas o fisiológicas

In lung cancer patients, DJ-1 (protein deglycase) acts as a biomarker for the initial prognosis. It also acts as a serum biomarker for identifying high-risk endometrial cancer.

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

nwg

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
310172

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Park7, a novel locus for autosomal recessive early-onset parkinsonism, on chromosome 1p36
van Duijn CM, et al.
American Journal of Human Genetics, 69(3), 629-634 (2001)
DJ-1 is a reliable serum biomarker for discriminating high-risk endometrial cancer
Di Cello A, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 39(6) (2017)
DJ-1 as a potential biomarker for the early diagnosis in lung cancer patients
Han B, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 39(6) (2017)
Lin Cheng et al.
Experimental and therapeutic medicine, 21(6), 557-557 (2021-04-15)
Studies have confirmed that DJ-1 is associated with diseases associated with the nervous system, including Alzheimer's disease (AD). However, the role of DJ-1 in the pathogenesis of AD has not been clarified. To investigate the effect of DJ-1 on brain
Kuldip D Dave et al.
Neurobiology of disease, 70, 190-203 (2014-06-28)
Recessively inherited loss-of-function mutations in the PTEN-induced putative kinase 1(Pink1), DJ-1 (Park7) and Parkin (Park2) genes are linked to familial cases of early-onset Parkinson's disease (PD). As part of its strategy to provide more tools for the research community, The

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