Key Documents
SAB4200884
Anti-Pseudomonas aeruginosa LPS antibody, Mouse monoclonal
clone PSL-52, purified from hybridoma cell culture
About This Item
Productos recomendados
antibody form
purified from hybridoma cell culture
Quality Level
clone
PSL-52
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
1 of 4
Este artículo | SAB4200878 | SAB4200871 | SAB4200859 |
---|---|---|---|
PSL-52 | Ecco14 | EXO-68 | SEB4 |
dry ice | dry ice | - | dry ice |
200 | 200 | 200 | 200 |
−20°C | −20°C | −20°C | −20°C |
unmodified | unmodified | unmodified | unmodified |
General description
Specificity
Application
Biochem/physiol Actions
P. aeruginosa cells possess a single flagellum and type 4 pili that are important for adhesion to the host epithelial cells, motility and can also initiate an inflammatory response.1 After adhesion, P. aeruginosa activates Type 3 secretion system (T3SS) and injects cytotoxins into the host cell.1 Moreover, P. aeruginosa secretes several proteases, which can degrade host complement, mucins, and disrupt tight junctions6-7,. In addition to lipases and phospholipases, that degrade lipids in host cell membranes6, and expresses Lipopolysaccharide (LPS), that is involved in inflammatory response and antibiotic resistance8.
Antibiotic resistance to many classes of antibiotics is a major challange in P. aeruginosa treatment. P. aeruginosa possesses several resistance mechanisms such as, low permeability of the outer membrane,
expression of membrane efflux (Mex) pumps, and β-lactamase and AmpC that hydrolases β-lactam antibiotics such as, penicillin9. In addition, as a result of genetic transfer new resistant strains emerge constantly. Therefore, finding new prevention and treatment strategies for P. aeruginosa infection is of high importance.1
Physical form
Storage and Stability
Disclaimer
Storage Class
12 - Non Combustible Liquids
wgk_germany
nwg
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