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Merck

SAB4200018

Sigma-Aldrich

Anti-Osteopontin antibody, Mouse monoclonal

clone OPN46, purified from hybridoma cell culture

Sinónimos:

Anti-BNSP, Anti-Bone Sialoprotein 1, Anti-Early T Lymphocyte Activation Protein 1 (ETA1), Anti-OPN, Anti-SPP1, Anti-Secreted phosphoprotein 1, Anti-Urinary stone protein, Anti-Uropontin

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100 MG
CHF 253,00
250 MG
CHF 341,40

Referencia (SKU) del distribuidor: EN300-83532-100MG

CHF 253,00


Disponibilidad
Se envía en 14 días desde el socio de Aldrich

To order products, please Contacto your local dealer.

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100 MG
CHF 253,00
250 MG
CHF 341,40

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Referencia (SKU) del distribuidor: EN300-83532-100MG

CHF 253,00


Disponibilidad
Se envía en 14 días desde el socio de Aldrich

To order products, please Contacto your local dealer.

biological source

mouse

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

OPN46, monoclonal

form

buffered aqueous solution

mol wt

antigen ~60 kDa

species reactivity

human, mouse, monkey, rat, canine

concentration

~1.0 mg/mL

technique(s)

western blot: 5-10 μg/mL using HepG2 cells extract

General description

Monoclonal Anti-Osteopontin (mouse IgG1 isotype) is derived from the hybridoma OPN46 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to amino acids of human osteopontin. Osteopontin (OPN) is a secreted, integrin-binding glycophosphoprotein which serves as a cytokine and as an extracellular matrix molecule. It is produced by multiple tissues in the body and is most abundant in bone.

Application

Monoclonal Anti-Osteopontin antibody produced in mouse may be used in immunoblotting.

Biochem/physiol Actions

Osteopontin (OPN) synthesized in cancer cells is essentail for growth, progression and metastasis of cancer. In tuomr cells OPN is highly expressed The structural features of OPN differ between normal and tumor cells Three osteopontin splice variant transcripts have been found to be expressed in invasive, but not in non-invasive breast tumor cell lines. Osteopontin-b lacks exon 5 and osteopontin-c lacks exon 4. The shortest splice variant, osteopontin-c may support breast tumor progression by conveying anchorage independence and inducing oxidoreductases expression. It was also suggested as a diagnostic and prognostic breast cancer marker.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Osteopontin-c is a selective marker of breast cancer
Mirza M
International Journal of Cancer. Journal International Du Cancer, 122(4), 889-897 (2008)
Osteopontin knockdown suppresses tumorigenicity of human metastatic breast carcinoma, MDA-MB-435
Shevde LA, et al.
Clinical & Experimental Metastasis, 23(2), 123-133 (2006)
Osteopontin: A novel regulator at the cross roads of inflammation, obesity and diabetes
Kahles F, et al.
Molecular Metabolism, 3(4), 384-393 (2014)
Role of osteopontin in the pathophysiology of cancer
Shevde LA and Samant RS
Matrix Biology, 37, 131-141 (2014)
An osteopontin splice variant induces anchorage independence in human breast cancer cells
He, B and Mirza, M and Weber, GF
Oncogene, 25(15), 2192-2192 (2006)

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

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