SAB2500809

Anti-PODXL antibody produced in goat

affinity isolated antibody, buffered aqueous solution

• Sinónimos: Anti-Gp200, Anti-MGC138240, Anti-PCLP, Anti-Podocalyxin-like
• UNSPSC Code: 12352203
• NACRES: NA.41

Propiedades

• biological source: goat
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: human, rat, mouse, canine
• technique(s): indirect ELISA: suitable; western blot: suitable
• UniProt accession no.: O00592
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... PODXL(5420)

Descripción

General description

PODXL (podocalyxin like) is an anti-adhesive transmembrane protein which belongs to the sialomucin protein family. It is associated with cancer development and aggressiveness. The protein is expressed in various cells including epithelial cells of kidney glomeruli, vascular endothelial cells, hematopoietic stem cells and platelets. The gene encoding PODXL is localized on human chromosome 7q32.3.

Immunogen

Peptide with sequence C-DNLTKDDLDEEEDTH from the C Terminus of the protein sequence according to NP_001018121.1 ; NP_005388.2.

Biochem/physiol Actions

PODXL (podocalyxin like) acts as an anti-adhesion molecule in kidney open filtration pathways. It interacts with the actin-binding protein ezrin in cancer. Using ezrin and the bridging protein NHERF (Na⁺/H⁺) exchanger regulatory factor, it connects to the cytoskeleton to regulate cytoskeletal-related functions in tumor progression. In human, PODXL stimulates the cell adherence capacity to immobilized ligands and vascular endothelial cells in presence of integrins.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable