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Merck

S5393

Sigma-Aldrich

Serum minus IgA/IgM/IgG human

lyophilized powder

Sinónimos:

Depleted Serum

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.46
En este momento no podemos mostrarle ni los precios ni la disponibilidad

origen biológico

human

Nivel de calidad

conjugado

unconjugated

Formulario

lyophilized powder

contiene

15 mM sodium azide

envase

vial of 0.5 mL

temp. de almacenamiento

2-8°C

modificación del objetivo postraduccional

unmodified

Descripción general

Serum is the liquid component of blood that includes proteins, immunoglobulin and electrolytes. The product can be used for selective removal of contaminating antibodies when immobilized on a solid matrix. This product can also be used in anti-protective antigen (anti-PA) IgG measurements using PA coupled microspheres[1]. Human serum deficient of IgG, IgA, and IgM can react specifically with anti-human whole serum but does not show reactivity with anti-human IgG, IgA, or IgM.

Aplicación

Serum minus IgA/IgM/IgG human has been used as a control serum in immunoelectrophoresis, immunodiffusion,enzyme linked immunosorbent assay. It has also been used as
  • control sera to assess neuraminidase inhibition[2]
  • microneutralization assay[3]
  • single radial hemolysis (SRH) repeatability assay[4]

Cantidad

Each vial contains at least 25 mg protein

Reconstitución

Reconstitute with 0.5 mL deionized water.

Cláusula de descargo de responsabilidad

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


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Method for Simultaneous Measurement of Antibodies to 23 Pneumococcal Capsular Polysaccharides
Raymond E. Biagini, Sonela A. Schlottmann
Clinical and Vaccine Immunology : CVI, 10(5), 744-750 (2003)
Claudia Maria Trombetta et al.
Influenza and other respiratory viruses, 12(6), 675-686 (2018-07-19)
The immunological response to influenza vaccine and/or natural infection is evaluated by serological techniques, the most common being hemagglutination inhibition (HI), single radial hemolysis (SRH), and virus neutralization assays, which is commonly used in a micro-neutralization (MN) format. ELISA is
Khin Myo Aye et al.
Journal of immunological methods, 462, 91-100 (2018-09-12)
Development of reliable, quantitative technologies for serodiagnosis of Toxoplasma gondii infection remains desirable. The luciferase immunoprecipitation system (LIPS) is a relatively simple, highly sensitive, and rapid quantitative immunoassay. The major advantages of this assay over ELISA are a wider dynamic
Marie-Clotilde Bernard et al.
Frontiers in immunology, 13, 909297-909297 (2022-07-06)
Current vaccination strategies against influenza focus on generating an antibody response against the viral haemagglutination surface protein, however there is increasing interest in neuraminidase (NA) as a target for vaccine development. A critical tool for development of vaccines that target
Claudia M Trombetta et al.
Viruses, 12(1) (2020-01-02)
Influenza D virus is a novel influenza virus, which was first isolated from an ailing swine in 2011 and later detected in cattle, suggesting that these animals may be a primary natural reservoir. To date, few studies have been performed

Questions

1–2 of 2 Questions  
  1. Are the serum proteins of human complement cascade still active in the product S5393?

    1 answer
    1. The presence of complement components and the activation cascade have not been investigated for this product. This is not included in the quality testing. However, the serum has not been heat inactivated. In theory, serum complement should still be present and the cascade system can be activated. The end user would have to determine the suitability of this product for compliment studies.

      Helpful?

  2. How is the serum treated to deplete it from IgG, IgA and IgM?

    1 answer
    1. Methods of preparation are considered proprietary.

      Helpful?

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