S3442

SB 216763

>98% (HPLC)

• Sinónimos: 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
• Fórmula empírica (notación de Hill): C₁₉H₁₂N₂O₂Cl₂
• Número de CAS: 280744-09-4
• Peso molecular: 371.22
• Número MDL: MFCD09753369
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 24278616
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: >98% (HPLC)
• color: orange
• solubilidad: DMSO: soluble 20 mg/mL; H₂O: insoluble
• emisor: GlaxoSmithKline
• temp. de almacenamiento: −20°C
• cadena SMILES: Cn1cc(C2=C(C(=O)NC2=O)c3ccc(Cl)cc3Cl)c4ccccc14
• InChI: 1S/C19H12Cl2N2O2/c1-23-9-13(11-4-2-3-5-15(11)23)17-16(18(24)22-19(17)25)12-7-6-10(20)8-14(12)21/h2-9H,1H3,(H,22,24,25)
• Clave InChI: JCSGFHVFHSKIJH-UHFFFAOYSA-N
• Información sobre el gen: human ... GSK3A(2931) , GSK3B(2932)

Descripción

Aplicación

SB-216763 was used to inhibit GSK-3β in human brain microvascular endothelial cell line and colorectal cancer cells.

Acciones bioquímicas o fisiológicas

Potent, selective, cell permeable glycogen synthase kinase-3 (GSK-3) inhibitor.

SB-216763 is a small molecule that competes with ATP and potently inhibits the activity α and β isozymes of GSK-3. It acts as neuroprotectant and prevents neuronal cell death induced by PI3-kinase pathway. It also delays preconditioning, reduces infarct size and prevents cardiac ischemia.

Características y beneficios

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GSK-3 and PKB/Akt pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Información legal

Sold for research purposes under agreement from Glaxo­Smith­Kline

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves