S0292

Silymarin

flavonolignans

• Sinónimos: flavolignans
• Número de CAS: 65666-07-1
• Número MDL: MFCD01776359
• Código UNSPSC: 12352202
• NACRES: NA.81

Propiedades

• origen biológico: plant (Silybum marianum)
• Nivel de calidad: 200
• Formulario: powder
• técnicas: toxicology assay: suitable
• aplicaciones: microbiology
• temp. de almacenamiento: −20°C
• cadena SMILES: O1C(C(Oc3c1ccc(c3)C4Oc5c(c(cc(c5)O)O)C(=O)C4O)c2cc(c(cc2)O)OC)CO
• InChI: 1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3
• Clave InChI: SEBFKMXJBCUCAI-UHFFFAOYSA-N

Descripción

Descripción general

Silymarin is a flavonolignan, obtained from milk thistle (Silybum marianum) plant.

Aplicación

Silymarin has been used to study:

• its in vitro antiviral, antibacterial, antifungal activities and cytotoxicity
• its effect of silymarin on bladder contractions in cyclophosphamide (CYP)-induced cystitis rat model
• its effect on liver toxication induced by Fumonisin B1 in mice

Acciones bioquímicas o fisiológicas

Silymarin is originally known to protect liver from various toxic agents and is used in treating hepatitis and cirrhosis. Silymarin possesses many biological actions such as antifibrotic, anti-lipid peroxidative, anti-inflammatory, immunomodulatory and membrane stabilizing. Silymarin also aids in liver regeneration.

Silymarin provides cardioprotective activity against ischemia-reperfusion induced myocardial infarction in rats.

Silymarin was shown to protect the liver from the cytotoxic effects of anti-tuberculosis drugs by decreasing serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) levels. This effect was related to the anti-oxidant effects of silymarin.

Otras notas

Mixture of anti-hepatotoxic flavonolignans from the fruit of Silybum marianum.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)