P9703

Pimaricin

from Streptomyces chattanoogensis, ≥95% (HPLC)

• Sinónimos: Natamycin
• Fórmula empírica (notación de Hill): C₃₃H₄₇NO₁₃
• Número de CAS: 7681-93-8
• Peso molecular: 665.73
• Número CE: 231-683-5
• Número MDL: MFCD00135085
• Código UNSPSC: 51102829
• ID de la sustancia en PubChem: 24899055
• NACRES: NA.85

Propiedades

• origen biológico: Streptomyces chattanoogensis
• Nivel de calidad: 300
• Ensayo: ≥95% (HPLC)
• Formulario: lyophilized powder; powder
• solubilidad: 0.1% formic acid in methanol: soluble 1 mg/mL
• espectro de actividad antibiótica: fungi
• aplicaciones: agriculture; environmental
• Modo de acción: cell membrane | interferes
• temp. de almacenamiento: 2-8°C
• cadena SMILES: C[C@@H]1C\C=C\C=C\C=C\C=C\[C@@H](C[C@@H]2O[C@](O)(C[C@@H](O)C[C@H]3O[C@@H]3\C=C\C(=O)O1)C[C@H](O)[C@H]2C(O)=O)O[C@@H]4O[C@H](C)[C@@H](O)[C@H](N)[C@@H]4O
• InChI: 1S/C33H47NO13/c1-18-10-8-6-4-3-5-7-9-11-21(45-32-30(39)28(34)29(38)19(2)44-32)15-25-27(31(40)41)22(36)17-33(42,47-25)16-20(35)14-24-23(46-24)12-13-26(37)43-18/h3-9,11-13,18-25,27-30,32,35-36,38-39,42H,10,14-17,34H2,1-2H3,(H,40,41)/b4-3+,7-5+,8-6+,11-9+,13-12+/t18-,19-,20+,21+,22+,23-,24-,25+,27-,28+,29-,30+,32+,33-/m1/s1
• Clave InChI: NCXMLFZGDNKEPB-FFPOYIOWSA-N

Descripción

Descripción general

Chemical structure: macrolide

Aplicación

Pimaricin is an amphoteric antibiotic from Streptomyces chattanoogensis. It is used for a variety of fungal infections, mainly topically. It is used as an ergosterol and cholesterol binding agent to study lipid bilayer dynamics, especially in fungal cells. Pimaricin is used as a fungicide in agar media. It is used to study the pleitropic regulator AdpAch and the gamma-butyrolactone regulatory system of Streptomyces chattanoogensis.

Acciones bioquímicas o fisiológicas

An antifungal polyene macrolide that binds specifically to ergosterol and blocks fungal growth. However, unlike nysatin and filipin, pimaricin does not change the permeability of the plasma membrane

Otras notas

Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8 °C. Light sensitive.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)