P1903
Pyruvate Kinase from Bacillus stearothermophilus
Type VIII, lyophilized powder, 100-300 units/mg protein
Sinónimos:
ATP:pyruvate 2-O-phosphotransferase, PK
About This Item
Productos recomendados
biological source
Bacillus sp. (B. stearothermophilus)
Quality Level
type
Type VIII
form
lyophilized powder
specific activity
100-300 units/mg protein
storage temp.
2-8°C
General description
Mammalian pyruvate kinase is a tetrameric protein composed of identical subunits organized in a dimer-of-dimers configuration. Four isoforms of pyruvate kinase exist in mammals, namely PKM1, PKM2, PKR, and PKL.[1] Pyruvate kinase can be found in both tetrameric and dimeric forms.[2]
Application
Biochem/physiol Actions
Pyruvate kinase is a key regulator controlling metabolic flux and ATP production in glycolysis and is considered a potential drug target. Additionally, pyruvate kinases are subject to regulation by heterotropic effectors, with fructose 1,6-bisphosphate (FBP) being the most widely known allosteric activator of bacterial, yeast, and mammalian enzymes.[2] Furthermore, PKM2, one of the four isoforms of pyruvate kinase, is extensively expressed in various types of tumors and is associated with tumorigenesis.[6]
Unit Definition
Physical form
Analysis Note
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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