P0040

PP1

≥98% (HPLC)

• Sinónimos: 4-Amino-5-(methylphenyl)-7-(t-butyl)pyrazolo-(3,4-d)pyrimidine
• Fórmula empírica (notación de Hill): C₁₆H₁₉N₅
• Número de CAS: 172889-26-8
• Peso molecular: 281.36
• Número MDL: MFCD01076570
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329819992
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• color: white to off-white
• solubilidad: DMSO: >20 mg/mL
• temp. de almacenamiento: room temp
• cadena SMILES: Cc1ccc(cc1)-c2nn(c3ncnc(N)c23)C(C)(C)C
• InChI: 1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19)
• Clave InChI: ZVPDNRVYHLRXLX-UHFFFAOYSA-N

Descripción

Aplicación

PP1 has been used as:

• an inhibitor of sarcoma (Src) family kinases (SFK) like hematopoietic cell kinase (hck) and fyn
• a selective Src tyrosine kinase inhibitor in hippocampal neuronal cultures to test its effect on neurite growth
• a Src-kinase blocker to test its effect on brimonidine (BMD)-induced phosphorylation in extracellular signal-activated kinases(ERK1/2)

Acciones bioquímicas o fisiológicas

PP1 is a potent and selective Src family protein tyrosine kinase inhibitor.

PP1 is a pyrazolopyrimidine compound that acts as a competitive inhibitor of adenosine triphosphate (ATP) binding. It also inhibits protein tyrosine kinase (PTK6) and may be useful in the therapeutic management of PTK6 positive based breast cancer malignancy.

Características y beneficios

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable