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N8133

Sigma-Aldrich

Nerve Growth Factor from Vipera lebetina venom

lyophilized powder, suitable for cell culture

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About This Item

Número de CAS:
9061-61-4
MDL number:
MFCD00147703
UNSPSC Code:
12352202
NACRES:
NA.77

product name

Nerve Growth Factor from Vipera lebetina venom, NGF, lyophilized powder, suitable for cell culture

biological source

Vipera Lebetina

Quality Level

200

form

lyophilized powder

potency

0.2-20 μg/mL ED50/EC50

quality

endotoxin tested

mol wt

protein 32.5 kDa

packaging

pkg of 0.1 mg

technique(s)

cell culture | mammalian: suitable

impurities

<10 EU/vial

color

white to off-white

UniProt accession no.

P25428

storage temp.

−20°C

Categorías relacionadas

Physical form

Lyophilized from a 0.2 μm filtered solution in sodium acetate buffer.

Preparation Note

Isolated from the snake venom of V. lebetina.

Analysis Note

The biological activity of Nerve Growth Factor (NGF) from Vipera lebetina venom is measured in a cell proliferation assay using PC-12 cells.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Sigma-Aldrich

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Cytarabine United States Pharmacopeia (USP) Reference Standard

USP

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Cytarabine

Giusi Prencipe et al.
Journal of immunology (Baltimore, Md. : 1950), 192(7), 3345-3354 (2014-03-04)
Nerve growth factor (NGF) levels are highly increased in inflamed tissues, but their role is unclear. We show that NGF is part of a regulatory loop in monocytes: inflammatory stimuli, while activating a proinflammatory response through TLRs, upregulate the expression
Lucy Hepburn et al.
Science (New York, N.Y.), 346(6209), 641-646 (2014-11-02)
Many key components of innate immunity to infection are shared between Drosophila and humans. However, the fly Toll ligand Spaetzle is not thought to have a vertebrate equivalent. We have found that the structurally related cystine-knot protein, nerve growth factor
Rachel T Uren et al.
Journal of neurochemistry, 129(4), 614-627 (2014-02-04)
Suppressor of cytokine signaling-2 (SOCS2) is a regulator of intracellular responses to growth factors and cytokines. Cultured dorsal root ganglia neurons from neonatal mice with increased or decreased SOCS2 expression were examined for altered responsiveness to nerve growth factor (NGF).
M Florencia Iulita et al.
Trends in pharmacological sciences, 35(7), 338-348 (2014-06-26)
Alzheimer's disease (AD) is a devastating neurodegenerative condition and the most common type of amnestic dementia in the elderly. Individuals with Down syndrome (DS) are at increased risk of developing AD in adulthood as a result of chromosome 21 trisomy
Federica De Angelis et al.
Journal of cellular physiology, 229(6), 783-790 (2013-10-30)
The peripheral application of the M2 cholinergic agonist arecaidine on sensory nerve endings shows anti-nociceptive properties. In this work, we analyze in vitro, the mechanisms downstream M2 receptor activation causing the analgesic effects, and in vivo the effects produced by
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