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Merck
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Key Documents

N7032

Sigma-Aldrich

NFAT Inhibitor

>96% (HPLC), solid

Sinónimos:

VIVIT

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About This Item

Fórmula empírica (notación de Hill):
C75H118N20O22S
Número de CAS:
249537-73-3
Peso molecular:
1683.93
MDL number:
MFCD02683959
UNSPSC Code:
12352202
NACRES:
NA.26

Quality Level

300

assay

>96% (HPLC)

form

solid

storage temp.

−20°C

InChI

1S/C75H118N20O22S/c1-12-39(7)59(90-70(111)57(37(3)4)88-68(109)52-19-16-27-95(52)74(115)49(30-44-32-78-36-82-44)87-67(108)51-18-15-26-94(51)53(97)33-79-62(103)41(9)83-63(104)45(76)24-28-118-11)72(113)89-58(38(5)6)71(112)91-60(40(8)13-2)73(114)92-61(42(10)96)69(110)80-34-54(98)93-25-14-17-50(93)66(107)86-48(29-43-31-77-35-81-43)65(106)84-46(20-22-55(99)100)64(105)85-47(75(116)117)21-23-56(101)102/h31-32,35-42,45-52,57-61,96H,12-30,33-34,76H2,1-11H3,(H,77,81)(H,78,82)(H,79,103)(H,80,110)(H,83,104)(H,84,106)(H,85,105)(H,86,107)(H,87,108)(H,88,109)(H,89,113)(H,90,111)(H,91,112)(H,92,114)(H,99,100)(H,101,102)(H,116,117)/t39-,40-,41-,42+,45-,46-,47-,48-,49-,50-,51-,52-,57-,58-,59-,60-,61-/m0/s1

InChI key

QPMHUXBSHGAVGD-MCDIZDEASA-N

Gene Information

human ... NFATC1(4772) , NFATC2(4773)
mouse ... Nfatc1(18018) , Nfatc2(18019)

Amino Acid Sequence

Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu

Application

NFAT Inhibitor, VIVIT has been used to study the signaling pathways involved in controlling inhibitory molecules and subsequent onset of T-cell impairment.
NFAT inhibitor has been as an inhibitor of nuclear factor of activated T cells.

Biochem/physiol Actions

High-affinity calcineurin-binding peptide that inhibits NFAT (Nuclear Factor of Activated T cells) activation and NFAT-dependent expression of endogenous cytokine genes in T cells.
Nuclear factor of activated T cells (NFAT) participates in the activity and growth of immune and non-immune cells.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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p38 Mitogen-Activated Protein Kinase/Signal Transducer and Activator of Transcription-3 Pathway Signaling Regulates Expression of Inhibitory Molecules in T Cells Activated by HIV-1?Exposed Dendritic Cells
Karlhans Fu Che
Molecular Medicine (2012)
Karlhans Fru Che et al.
Molecular medicine (Cambridge, Mass.), 18, 1169-1182 (2012-07-11)
Human immunodeficiency virus type 1 (HIV-1) infection enhances the expression of inhibitory molecules on T cells, leading to T-cell impairment. The signaling pathways underlying the regulation of inhibitory molecules and subsequent onset of T-cell impairment remain elusive. We showed that

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