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Merck

MTOX1002P24

Sigma-Aldrich

BCRP Knockout Caco-2 Cells

human cervix, Epithelial

Sinónimos:

BCRP Knockout C2BBe1 Cells

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About This Item

UNSPSC Code:
41106514
NACRES:
NA.81

product name

BCRP Knockout Caco-2 Cells, one assay ready, 24 well plate

biological source

human colon

form

solid

morphology

Epthelial

technique(s)

drug transporter assay: suitable
permeability assay: suitable

application(s)

ADME/TOX

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General description

The C2BBe1 cells, a subclone of Caco-2 cells, correspond to ATCC CRL-2102. The BCRP knockout C2BBe1 cells are adenocarcinoma, epithelial cells from a human caucasian male (aged 72 years) with functional knockout of the BCRP efflux transporter.

The three week production lead time begins on the Monday following a purchase, in the third week the plates are shipped on Tuesday for receipt on Wednesday or Thursday. As a biologic product that′s shipped at room temperature the cells must be processed immediately upon receipt.

Features and Benefits

The Caco-2 subclone, C2BBe1 cells, are ideal for transporter analysis as they express multiple transporters, are human derived and grow in a homogenous monolayer that forms tight juntions which is necessary for efflux ratio analysis. Other benefits include:

  • A functional knockout of the BCRP gene eliminates the reliance on chemical inhibitors to determine if a compound is an MDR1 substrate
  • The 24 well Transwell format enables the BCRP knockout cells to be included in standard drug transporter protocols
  • Human assay with no interference from animal inhibitors
  • Overcome the limitations of RNAi and knockdown cell lines that arise from remaining transporter functionality

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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