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Merck
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Key Documents

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M6502

Sigma-Aldrich

6-Methylpurine

≥99%

Sinónimos:

MeP

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About This Item

Fórmula empírica (notación de Hill):
C6H6N4
Número de CAS:
2004-03-7
Peso molecular:
134.14
EC Number:
217-903-2
MDL number:
MFCD00083663
UNSPSC Code:
41106305
PubChem Substance ID:
24897013
NACRES:
NA.51

biological source

synthetic (organic)

Quality Level

100

assay

≥99%

form

powder

mp

237-238 °C (lit.)

solubility

water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

storage temp.

−20°C

SMILES string

Cc1ncnc2[nH]cnc12

InChI

1S/C6H6N4/c1-4-5-6(9-2-7-4)10-3-8-5/h2-3H,1H3,(H,7,8,9,10)

InChI key

SYMHUEFSSMBHJA-UHFFFAOYSA-N

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Application

6-Methylpurine (MeP) is a toxic adenine analog used as a bisubstrate inhibitor of enzymes that bind adenosyl moieties and which may become phosphorylated to levels that inhibit RNA and protein synthesis.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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H Ohgaki et al.
Journal of cancer research and clinical oncology, 117(1), 13-18 (1991-01-01)
The formation of O6-methyldeoxyguanosine (O6-MedGuo) was determined by an immuno-slot-blot assay in DNA of various tissues of F344 rats exposed to N-methyl-N-nitrosourea (MNU) in the drinking water at 400 ppm for 2 weeks. Although the pyloric region of the glandular
L J Lockett et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 3(11), 2075-2080 (1998-11-17)
Enzyme-prodrug therapy for the treatment of cancer is an experimental procedure that is under intensive investigation. However, the relative merits of the various systems for use under specific conditions are still being determined. We have compared the efficacy of cell
Hoonsik Yoom et al.
The Science of the total environment, 634, 677-686 (2018-04-12)
The reaction kinetics, products, and pathways of methylparaben (MeP) during water chlorination with and without bromide (Br-) were investigated to better understand the fate of parabens in chlorinated waters. During the chlorination of MeP-spiked waters without Br-, MeP was transformed
Paromita Chakraborty et al.
Environmental pollution (Barking, Essex : 1987), 249, 1071-1080 (2019-05-31)
The Hooghly River (HR) estuary is the first deltaic off-shoot of the perennial and transboundary river, Ganga, India. HR receives industrial and domestic waste along with storm-water run-off from Kolkata city and the adjoining districts. Organic micropollutants (OMPs) have been
Yingxin Yu et al.
Ecotoxicology and environmental safety, 182, 109419-109419 (2019-07-14)
Parabens are a kind of preservatives widely used in cosmetic and personal care products and ubiquitously detected in the environment. However, little is known on human exposure to these chemicals. Our study mainly investigated the urinary parabens in adults from
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