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I0406

Sigma-Aldrich

IL-6 rat

>97% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous solution, suitable for cell culture

Sinónimos:

Interleukin-6 from rat

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About This Item

Número MDL:
MFCD01323739
Código UNSPSC:
12352202
NACRES:
NA.77

Nombre del producto

Interleukin-6 from rat, IL-6, recombinant, expressed in E. coli, buffered aqueous solution, suitable for cell culture

origen biológico

rat

Nivel de calidad

200

recombinante

expressed in E. coli

Ensayo

>97% (SDS-PAGE)

Formulario

buffered aqueous solution

potencia

0.01-0.06 ng/mL ED50

calidad

endotoxin tested

mol peso

predicted mol wt ~22 kDa

envase

pkg of 10 and 50 μg

técnicas

cell culture | mammalian: suitable

impurezas

<0.01EU/mg (LAL test)

Nº de acceso UniProt

P20607.1

Condiciones de envío

dry ice

temp. de almacenamiento

−70°C

Información sobre el gen

rat ... Il6(24498)

Categorías relacionadas

Acciones bioquímicas o fisiológicas

Interleukin-6 (IL-6) is a multifunctional protein originally discovered in the media of cells stimulated with double stranded RNA. IL-6 appears to be directly involved in the responses that occur after infection and injury and may prove to be as important as IL-1 and TNF-α in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages, and endothelial cells. It acts upon a variety of cells, including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. IL-6 induces multiple effects, as indicated by its numerous synonyms: plasmacytoma growth factor (PCT-GF), interferon-β-2 (IFN-β2), monocyte derived human B cell growth factor, B cell stimulating factor (BSF-2), hepatocyte stimulating factor (HSF), Interleukin Hybridoma/Plasmacytoma-1 (IL-HP1). In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 also potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors.

Forma física

Supplied as a 0.2 μm filtered solution in 50 mM sodium acetate, pH 4, with BSA as a carrier protein.

Nota de preparación

Recombinant, rat Interleukin-6 is produced from a DNA sequence encoding the mature rat IL-6 protein. The methionyl form of mature rat IL-6, a 188 amino acid protein, has a predicted molecular mass of approx. 22 kDa. Rat and mouse IL-6 share 93% amino acid sequence identity.

Nota de análisis

The biological activity is measured in a cell proliferation assay using IL-6 dependent mouse plasmacytoma cell line, T1165.85.2.1.

Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
SLCN4225
SLBX6207
SLBX1145
SLBS0220V
SLBR7301V

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P W Bodell et al.
Journal of applied physiology (Bethesda, Md. : 1985), 106(2), 443-453 (2008-12-06)
Childhood diseases are often accompanied by chronic inflammation, which is thought to negatively impact growth. Interleukin-6 (IL-6) is typically cited as an indicator of inflammation and is linked to impaired growth. This study was designed to isolate and identify potential
Elin Banke et al.
Metabolism: clinical and experimental, 63(6), 831-840 (2014-04-02)
The bacteria Staphylococcus aureus is part of the normal bacterial flora and produces a repertoire of enterotoxins which can cause food poisoning and toxic shock and might contribute to the pathogenesis of inflammatory diseases. These enterotoxins directly cross-link the T
Lorena M Amaral et al.
American journal of obstetrics and gynecology, 211(2), 158-158 (2014-02-20)
Preeclampsia is a multisystem disorder recognized as hypertension with proteinuria developing >20 weeks' gestation. Preeclampsia is associated with chronic immune activation characterized by increased T and B lymphocytes, cytokines, and antibodies activating the angiotensin II type I receptor (AT1-AA). Hypertension
Mingming Zhang et al.
PloS one, 9(10), e109146-e109146 (2014-10-03)
It has been shown that Faecalibacterium prausnitzii (F. prausnitzii), one of the dominant intestinal bacterial flora, may protect colonic mucosa against the development of inflammation and subsequent inflammatory bowel disease (IBD), with the underlying mechanisms being unclear. The impacts of
A O'Toole et al.
British journal of cancer, 111(5), 927-932 (2014-07-25)
Tumour microenvironment (TME) of advanced colorectal cancer (CRC) suppresses dendritic cell (DC) maturation. Here, our aim was to determine how the microenvironment of early-stage tumours influences DCs. Tumour-conditioned media (TCM) was generated by culturing explant tumour tissue in vitro (n=50).
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