H5505
Histone from calf thymus
Type III-S
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About This Item
Productos recomendados
origen biológico
bovine (calf) thymus
Nivel de calidad
tpo
Type III-S
Formulario
powder
concentración
≥60% protein (biuret)
técnicas
activity assay: suitable
solubilidad
H2O: soluble 10 mg/mL, clear to hazy, colorless to light yellow
temp. de almacenamiento
2-8°C
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Aplicación
Histone is suitable for use:
- as a positive control in the in vitro kinase assay to examine the ability of Cdc2-cyclin B1 to phosphorylate GST-CD-4 protein
- in Cdk5 activity assay
- in histone H1 kinase assay
- as a Poly(ADP-ribose) (PAR) acceptor in the assessment of in vitro PAR polymerase activity
- as an acceptor of 32P from [γ-32P]ATP in order to measure protein kinase activity of lysate from small and large luteal cells
Acciones bioquímicas o fisiológicas
Histones are a group of proteins characterized by high levels of lysine and arginine that form reversible complexes with DNA. Based on the fractions, the molar mass of histones varies between 11-21kDa. Five different fractions have been isolated and characterized. They include H1 (lysine rich), H2a and H2b that are slightly lysine rich, H3 and H4 that are arginine rich. H1 acts as a link between "beads" (nu bodies) on the chromatin chain.
Características y beneficios
Do not confuse Sigma "Type" designations with the "Fraction" designations used by Luck and co-workers.
Otras notas
Characterized as mainly subgroup f1 by SDS-PAGE
Nota de preparación
Lysine-rich fraction as isolated and described by de Nooij, E. and Westenbrink, H.G., Biochim. Biophys. Acta, 62, 608 (1962).
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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