Saltar al contenido
Merck
Todas las fotos(1)

Documentos clave

Ver Toda la documentación

H4791

Sigma-Aldrich

BMP2, human

BMP-2, recombinant, expressed in HEK 293 cells, HumanKine, suitable for cell culture

Sinónimos:

Bone Morphogenetic Protein 2 human, BMP-2

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(1)

About This Item

Número MDL:
MFCD03097877
Código UNSPSC:
12352202
NACRES:
NA.77

Nombre del producto

Bone Morphogenetic Protein 2 human, BMP-2, recombinant, expressed in HEK 293 cells, HumanKine, suitable for cell culture

origen biológico

human

Nivel de calidad

100

recombinante

expressed in HEK 293 cells

Formulario

lyophilized powder

potencia

≤60 ng/mL EC50

calidad

endotoxin tested

mol peso

dimer 30-38 kDa (glycosylated)

envase

pkg of 10 μg

condiciones de almacenamiento

avoid repeated freeze/thaw cycles

técnicas

cell culture | mammalian: suitable

impurezas

≤1 EU/μg Endotoxin level

Nº de acceso UniProt

P12643

temp. de almacenamiento

−20°C

Información sobre el gen

human ... BMP2(650)

¿Está buscando productos similares? Visita Guía de comparación de productos

Categorías relacionadas

Descripción general

Bone Morphogenetic Protein 2 is a member of the TGF-β superfamily of cytokines that affect bone and cartilage formation. It is important for skeletal development during embryogenesis. BMP-2 induces chondrocyte formation, osteoblast differentiation, and is involved in embryo dorsal-ventral patterning and organogenesis.

Acciones bioquímicas o fisiológicas

It has been reported that Bone Morphogenetic Protein 2 (BMP-2) inhibits estradiol induced proliferation of human breast cancer cells. BMP-2 signaling mediates apoptosis by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6. Cellular responses to BMP-2 are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors, which play significant roles in BMP binding and signaling. One BMP type II receptor and two BMP type I receptors have been identified. Both BMP type I receptors bind BMP-2 with high-affinity in the absence of BMP receptor type II.

Forma física

Lyophilized from a 0.2 μm filtered solution of 2x PBS + 6% Ethanol.

Nota de preparación

This Bone Morphogenetic Protein 2 (BMP-2) is produced from a DNA sequence encoding the human BMP-2 protein, expressed in HEK 293 cells. It is a glycosylated homodimer linked by a single disulfide bond with an apparent molecular mass of 30-38 kDa.

Nota de análisis

The specific activity was determined by its ability to induce alkaline phosphatase production in a dose response to BMP-2 in the ATDC-5 cell line (mouse chondrogenic cell line).

Información legal

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Elija entre una de las versiones más recientes:

Certificados de análisis (COA)

Lot/Batch Number
MKCV6912
MKCV1375
MKCT8348
MKCV2222
MKCJ3393

¿No ve la versión correcta?

Si necesita una versión concreta, puede buscar un certificado específico por el número de lote.

Busque por un COA

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Moulay Hicham Alaoui-Ismaili et al.
Cytokine & growth factor reviews, 20(5-6), 501-507 (2009-11-17)
Bone morphogenetic proteins (BMPs) are growth factors belonging to the TGF beta super family. To date, more than twenty human BMPs have been identified. Of these, BMP-2 and BMP-7 (also known as osteogenic protein 1 or OP-1) are the only
Zhi-Jie Xia et al.
Frontiers in cell and developmental biology, 10, 979096-979096 (2022-11-18)
Saul-Wilson syndrome is a rare skeletal dysplasia caused by a heterozygous mutation in COG4 (p.G516R). Our previous study showed that this mutation affected glycosylation of proteoglycans and disturbed chondrocyte elongation and intercalation in zebrafish embryos expressing the COG4p.G516R variant. How
Yinbo Xiao et al.
Materials today. Bio, 16, 100367-100367 (2022-08-09)
Mesenchymal stem cell (MSC)-based tissue engineering strategies are of interest in the field of bone tissue regenerative medicine. MSCs are commonly investigated in combination with growth factors (GFs) and biomaterials to provide a regenerative environment for the cells. However, optimizing
Ernst B Hunziker et al.
Tissue engineering. Part A, 21(13-14), 2089-2098 (2015-04-22)
The articular cartilage layer of synovial joints is commonly lesioned by trauma or by a degenerative joint disease. Attempts to repair the damage frequently involve the performance of autologous chondrocyte implantation (ACI). Healthy cartilage must be first removed from the
Bo Shuai et al.
BMC complementary and alternative medicine, 15, 250-250 (2015-07-25)
Qing'e formula (QEF), prepared from an ancient Chinese recipe, was previously suggested to regulate bone metabolism and improve bone mineral density in patients with osteoporosis. To study the effects of medicated serum containing QEF on the in vitro differentiation of
Ver todos los artículos relacionados

Artículos

Injectable Hydrogels for Tissue Regeneration

Hydrogel-based biomaterials for cell delivery and tissue regeneration applications are discussed.

Injectable Hydrogels for Tissue Regeneration

Hydrogel-based biomaterials for cell delivery and tissue regeneration applications are discussed.

Injectable Hydrogels for Tissue Regeneration

Hydrogel-based biomaterials for cell delivery and tissue regeneration applications are discussed.

Injectable Hydrogels for Tissue Regeneration

Hydrogel-based biomaterials for cell delivery and tissue regeneration applications are discussed.

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico