G6129

Guanosine 3′,5′-cyclic monophosphate sodium salt

≥99% (HPLC), powder

• Sinónimos: 3′,5′-Cyclic GMP monosodium salt, 3′,5′-cGMP-Na, Guanosine 3′,5′-cyclophosphate monosodium salt, cGMP, cyclic GMP
• Fórmula empírica (notación de Hill): C₁₀H₁₁N₅NaO₇P
• Número de CAS: 40732-48-7
• Peso molecular: 367.19
• Beilstein/REAXYS Number: 6467425
• EC Number: 255-056-0
• MDL number: MFCD00038424
• UNSPSC Code: 41106305
• PubChem Substance ID: 24895245
• NACRES: NA.77

Propiedades

• Quality Level: 200
• assay: ≥99% (HPLC)
• form: powder
• color: white
• solubility: H₂O: 50 mg/mL
• storage temp.: −20°C
• SMILES string: [Na+].NC1=Nc2c(ncn2[C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)C(=O)N1
• InChI: 1S/C10H12N5O7P.Na/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6;/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17);/q;+1/p-1/t3-,5-,6-,9-;/m1./s1
• InChI key: KMPIYXNEROUNOG-GWTDSMLYSA-M

Descripción

Biochem/physiol Actions

An important second messenger, cGMP is a major intracellular mediator of extracellular signals such as nitric oxide and natriuretic peptides. Cyclic GMP interacts with three types of intracellular receptor proteins: cGMP-dependent protein kinases, cGMP-regulated channels, and cGMP-regulated cyclic nucleotide phosphodiesterases. A primary action of elevated cGMP levels in vivo is the stimulation of cGMP-dependent protein kinase (PKG).

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphodiesterases and PKA & PKG pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)