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Merck
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E1279

Sigma-Aldrich

Enoximone

solid

Sinónimos:

1,3-Dihydro-4-methyl-5-(4-methylthiobenzoyl)-2H-imidazol-2-one

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About This Item

Fórmula empírica (notación de Hill):
C12H12N2O2S
Número de CAS:
77671-31-9
Peso molecular:
248.30
Número MDL:
MFCD00867130
Código UNSPSC:
41106305
ID de la sustancia en PubChem:
24278408
NACRES:
NA.77

Formulario

solid

Nivel de calidad

100

color

light yellow

solubilidad

DMSO: soluble 28 mg/mL

cadena SMILES

CSc1ccc(cc1)C(=O)C2=C(C)NC(=O)N2

InChI

1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-6H,1-2H3,(H2,13,14,16)

Clave InChI

ZJKNESGOIKRXQY-UHFFFAOYSA-N

Información sobre el gen

human ... PDE3A(5139) , PDE3B(5140)

Acciones bioquímicas o fisiológicas

Selective phosphodiesterase III (PDE3) inhibitor. Prevents the degradation of cAMP by PDE.
Selective phosphodiesterase III (PDE3) inhibitor. Prevents the degradation of cAMP by PDE. Increased cAMP results in enhanced contractility of the heart.

Características y beneficios

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000239177
0000177485
074M4622V
075K4610
042K4601

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E Jähnchen et al.
Zeitschrift fur Kardiologie, 80 Suppl 4, 21-26 (1991-01-01)
Enoximone belongs to the imidazole class of compounds, that possess positive inotropic and vasodilatory activities. These pharmacologic effects are caused by selective inhibition of a cAMP-specific phosphodiesterase in the heart and in the smooth muscle of blood vessels. Results obtained
Marco Metra et al.
European heart journal, 30(24), 3015-3026 (2009-08-25)
Use of inotropic agents in patients with heart failure (HF) has been limited by adverse effects on outcomes. However, administration of positive inotropes at lower doses and concomitant treatment with beta-blockers might increase benefit-risk ratio. We investigated the effects of
D Trenk et al.
Zeitschrift fur Kardiologie, 83 Suppl 2, 7-14 (1994-01-01)
Enoximone is an imidazole derivative which proved to be a selective inhibitor of the isoenzymes III/IV of the cAMP-specific phosphodiesterase. It has been shown in various experimental models that the drug exerts both positive inotropic and vasodilating properties which can
Stijn Schauvliege et al.
Veterinary anaesthesia and analgesia, 35(4), 306-318 (2009-06-16)
To evaluate the combined effects of enoximone and dobutamine on the cardiovascular system and respiratory gas exchange in isoflurane-anaesthetized ponies. Prospective, randomized, experimental study. Six ponies (286 +/- 52 kg), aged 5.0 +/- 1.6 years. After sedation (romifidine 80 microg
R C Dage et al.
Cardiology, 77 Suppl 3, 2-13 (1990-01-01)
Enoximone is an inotropic vasodilating agent. Its principal effects are positive inotropism and vasodilation, which are not accompanied by changes in myocardial oxygen consumption. An inotropic dose of enoximone increases the level of cyclic AMP in the isolated, blood-perfused dog
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