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D4540

Sigma-Aldrich

Dimetilsulfóxido

Dimethyl sulfoxide
1 of 2 reviewers received a sample product or took part in a promotion

≥99.5% (GC), suitable for plant cell culture

Sinónimos:

DMSO

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About This Item

Fórmula lineal:
(CH3)2SO
Número de CAS:
67-68-5
Peso molecular:
78.13
Beilstein/REAXYS Number:
506008
EC Number:
200-664-3
MDL number:
MFCD00002089
UNSPSC Code:
12191502
PubChem Substance ID:
24893881
NACRES:
NA.71
assay:
≥99.5% (GC)
technique(s):
cell culture | plant: suitable
cryopreservation: suitable
bp:
189 °C (lit.)
vapor pressure:
0.42 mmHg ( 20 °C)
En este momento no podemos mostrarle ni los precios ni la disponibilidad

vapor density

2.7 (vs air)

Quality Level

200

vapor pressure

0.42 mmHg ( 20 °C)

assay

≥99.5% (GC)

form

liquid

autoignition temp.

573 °F

expl. lim.

42 %, 63 °F

technique(s)

cell culture | plant: suitable
cryopreservation: suitable

impurities

<0.1% water (Karl Fischer)

color

colorless

refractive index

n20/D 1.479 (lit.)

bp

189 °C (lit.)

mp

16-19 °C (lit.)

solubility

H2O: miscible (completely)

density

1.10 g/mL (lit.)

SMILES string

CS(C)=O

InChI

1S/C2H6OS/c1-4(2)3/h1-2H3

InChI key

IAZDPXIOMUYVGZ-UHFFFAOYSA-N

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Application

El dimetilsulfóxido se ha utilizado:
  • en la preparación de bisfenol A (BPA)[1]
  • en ensayos de proliferación celular (ensayo de MTT)[2]
  • en ensayos de quimiosensibilidad[3]
  • como vehículo control en todos los experimentos como los análisis de apoptosis[4]
  • en el ensayo de la O-desetilación de la etoxiresorufina (EROD)[5]

Biochem/physiol Actions

El DMSO (dimetilsulfóxido), un disolvente orgánico, posee diversas actividades farmacéuticas, tales como efectos analgésicos, diuréticos, bacteriostáticos, antiinflamatorios, vasodilatadores e inhibidores de la colinesterasa, además de capacidad para penetrar a través de la membrana.[6] Es un producto secundario de la industria maderera y se utiliza como un disolvente industrial. El DMSO sirve también como agente terapéutico para tratar la cistitis intersticial y la artritis.[7]

Caution

Fácilmente superenfriado, vuelve a fundir lentamente a temperatura ambiente. Producto solidificado que puede volver a licuarse por calentamiento a temperatura ambiente sin detrimento del producto.

Other Notes

Ganador del premio CiteAb 2024 como proveedor de éxito en la investigación del Parkinson

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

188.6 °F - closed cup

flash_point_c

87 °C - closed cup

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

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Certificados de análisis (COA)

Lot/Batch Number
BCCM3828
SHBR8759
BCCL4606
SHBR0085
SHBR2409

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Visite la Librería de documentos

Curcumin promotes apoptosis, increases chemosensitivity, and inhibits nuclear factor kappaB in esophageal adenocarcinoma
Hartojo W, et al.
Translational Oncology, 3(2), 99-108 (2010)
Pharmacotherapy of joint and tendon disease
Equine Sports Medicine and Surgery E-Book: Basic and clinical sciences of the equine athlete, 473-473 (2013)
Evaluation of the sub-lethal toxicity of Cu, Pb, bisphenol A and polychlorinated biphenyl to the marine dinoflagellate Cochlodinium polykrikoides
Ebenezer V and Ki J S
Algae, 27(1), 63-63 (2012)
2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1, and 19 in H295R human adrenocortical carcinoma cells
Sanderson J T, et al.
Toxicological Sciences, 61(1), 40-48 (2001)
Evaluation of Tualang honey as a supplement to fetal bovine serum in cell culture
Kannan, et al.
Food And Chemical Toxicology, 47(7) (2009)
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Overview of good cell banking practices for cell line cryopreservation purposes.

Good Cell Banking Practices

Overview of good cell banking practices for cell line cryopreservation purposes.

Good Cell Banking Practices

Overview of good cell banking practices for cell line cryopreservation purposes.

Good Cell Banking Practices

Overview of good cell banking practices for cell line cryopreservation purposes.

2 Reviews This action will navigate to reviews.

Questions

1–10 of 11 Questions  

  1. Can I use this product (suitable for plant cell culture) for cyropreservation of mammalian cells? Does cryopreservation of mammalian cells require sterile-filtered DMSO?

    1 answer

    1. D4540 is listed as suitable for cryopreservation.
      However, D2650 is already pre-sterile and has documentation with a protocol for cryopreservation of human and animal cell lines.

      See these links:
      https://www.sigmaaldrich.com/product/sigma/d2650
      https://www.sigmaaldrich.com/product/sigma/d2650#product-documentation

      Look for the Product Information Sheet. Also, see this link for more information:
      https://www.sigmaaldrich.com/products/cell-culture-and-analysis/cell-culture-supplements-and-reagents/cell-freezing-reagents

      Helpful?

  2. Can I autoclave this product?

    1 answer

    1. DMSO is not autoclavable in neat form. It is highly unlikely that microorganisms would survive in this environment. Should sterilization be necessary a PTFE, Polypropylene, or Nylon filter membrane are recommended for sterile-filtration.

      Helpful?

  3. What is the DMSO dissolved in?

    1 answer

    1. DMSO is not dissolved in any solvent. It is a pure chemical compound that is a liquid at room temperature.

      Helpful?

  4. What concentration of DMSO do I use in a cell freezing media?

    1 answer

    1. DMSO is usually used at 1-10%, depending on the cell line.  For the cell freezing media that we offer, it is used at 8.7% concentration.

      Helpful?

  5. Does DMSO have any synthetic utility?

    1 answer

    1. DMSO has been used to oxidize thiols and disulfides to sulfonic acids, hydrolysis of epoxides, thioalkylation of phenols, and oxidation of primary alcohols and halides, and esters of primary alcohols to aldehydes.

      Helpful?

  6. What type of filter is used to sterile-filter Dimethyl sulfoxide (DMSO)?

    1 answer

    1. DMSO can be sterile-filtered through a 0.2 micron PTFE filter. The sterility testing is per the current US Pharmacopoeia method.

      Helpful?

  7. Where does DMSO come from?

    1 answer

    1. DMSO is known to have been isolated from tree bark in the past. It is now a commericially synthesized solvent.

      Helpful?

  8. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

      Helpful?

  9. What is the molarity of DMSO?

    1 answer

    1. DMSO will have a molarity of 14.1M, based on a density of 1.1 g/mL and a molecular weight of 78.13 g/mol.

      Helpful?

  10. Dimethyl sulfoxide (DMSO) should be a liquid.  Why did it arrive as a solid?

    1 answer

    1. DMSO supercools easily, and re-melts slowly at room temperature. The melting point is 16-19 °C. The solidified product can be re-liquefied by warming to room temperature without detriment to the product.

      Helpful?

1–10 of 11 Questions  

Reviews

1 of 2 reviewers received a sample product or took part in a promotion

Active Filters

  1. San Diego
    • Review 1
    • Votes 3
    5 out of 5 stars.

    Works on mammalian cells

    Good for mammalian cell culture treatments of compound

    Helpful?

  2. 1 Ratings-Only Review

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