The melting point is 247-248°C.
D054
R(+)-SCH-23390 hydrochloride
≥98% (HPLC), solid
Sinónimos:
R(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
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About This Item
Fórmula empírica (notación de Hill):
C17H18ClNO · HCl
Número de CAS:
Peso molecular:
324.24
Número MDL:
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
NACRES:
NA.77
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Nivel de calidad
Ensayo
≥98% (HPLC)
Formulario
solid
actividad óptica
[α]/D +32.1°, c = 1 in DMF(lit.)
condiciones de almacenamiento
desiccated
protect from light
color
white
solubilidad
H2O: >5 mg/mL
cadena SMILES
Cl[H].CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c3ccccc3
InChI
1S/C17H18ClNO.ClH/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12;/h2-6,9-10,15,20H,7-8,11H2,1H3;1H/t15-;/m1./s1
Clave InChI
OYCAEWMSOPMASE-XFULWGLBSA-N
Información sobre el gen
human ... DRD1(1812)
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Aplicación
R(+)-SCH-23390 hydrochloride has been used:
- for intraperitoneal injection into experimental rats to study the role of D1 receptor in sensitization[1]
- as a D1 receptor-selective antagonist for intracranial drug infusions[2]
- as an antagonist of D1 receptor to study its effect on learning ability in fish[3]
Acciones bioquímicas o fisiológicas
R(+)-SCH-23390 hydrochloride is a selective D1 dopamine receptor antagonist. It has greater binding capacity towards 5-hydroxytryptamine 2 (5-HT2) and 5-HT1C serotonin receptor subtypes in in vitro. R(+)-SCH-23390 has a half-life of about 25 minutes after administration. It is known to possess anti-stereotypic effect and cataleptogenic effect. It also has inhibitory effect on motor activity.[4]
Características y beneficios
This compound is featured on the Dopamine Receptors and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Información legal
Sold with the permission of Schering-Plough.
Código de clase de almacenamiento
13 - Non Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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Certificados de análisis (COA)
Lot/Batch Number
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Los clientes también vieron
Stimulation of dopamine D1 receptor improves learning capacity in cooperating cleaner fish
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Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character. Royal Society (Great Britain), 283(1823), 20152272-20152272 (2016)
L C Iorio et al.
The Journal of pharmacology and experimental therapeutics, 226(2), 462-468 (1983-08-01)
SCH 23390 [R-(+)-8-chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol) possesses pharmacologic effects similar to standard antipsychotics, including selective supression of conditioned avoidance responding in rats and squirrel monkeys, blockade of apomorphine-induced stereotypy in rats and blockade of methamphetamine-induced lethality in aggregated mice. At effective doses in
A Sidhu et al.
European journal of pharmacology, 128(3), 213-220 (1986-09-09)
[125I]SCH 23982, [125I]8-iodo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepine-7-ol, binds reversibly and with high affinity (Kd = 0.7 +/- 0.05 nM) to specific binding sites (maximum binding = 108 +/- 3.5 fmol/mg) in the caudate nucleus of the rat brain. The caudate binding site displays pharmacological
SCH 23390: the first selective dopamine D1-like receptor antagonist
Bourne James A
Cns Drug Reviews, 7(4), 399-414 (2001)
Rewarding properties of methylphenidate: sensitization by prior exposure to the drug and effects of dopamine D1-and D2-receptor antagonists
Meririnne E, et al.
Journal of Pharmacology and Experimental Therapeutics, 298(2), 539-550 (2001)
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What is the melting point of Product D054, R(+)-SCH-23390 hydrochloride?
1 answer-
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Is Product D054, R(+)-SCH-23390 hydrochloride, light sensitive?
1 answer-
Yes, D054 is light sensitive. The powder form of the product, as well as solutions of the product, need to be protected from light.
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How does the storage temperature relate to shipping conditions?
1 answer-
The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.
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How do I dissolve Product D054, R(+)-SCH-23390 hydrochloride?
1 answer-
The D054 is tested for solublity in water at > 5 mg/mL. The product is also reported to be soluble in DMSO at 3mg/mL, and in ethanol at 2 mg/mL.
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Is Product D054, R(+)-SCH-23390 hydrochloride, only selective for the D1 dopamine receptor antagonist?
1 answer-
The D054 is a selective D1 dopamine receptor antagonist, but is also selective to the D5.
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What is the solution stability of Product D054, R(+)-SCH-23390 hydrochloride?
1 answer-
Solutions may be stored for approximately 24 hours at 2-8 °C, protected from exposure to light.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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