C6348
Monoclonal Anti-CXCR2 (IL-8 RB) antibody produced in mouse
clone 48311, purified immunoglobulin, lyophilized powder
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About This Item
Productos recomendados
origen biológico
mouse
Nivel de calidad
conjugado
unconjugated
forma del anticuerpo
purified immunoglobulin
tipo de anticuerpo
primary antibodies
clon
48311, monoclonal
Formulario
lyophilized powder
reactividad de especies
human
técnicas
flow cytometry: suitable
neutralization: suitable
isotipo
IgG2a
temp. de almacenamiento
−20°C
modificación del objetivo postraduccional
unmodified
Información sobre el gen
human ... IL8RB(3579)
mouse ... Il8rb(12765)
Categorías relacionadas
Descripción general
The antibody will neutralize human cell surface CXCR-2 mediated-myloperoxidase release from human granulocytes induced by GROα. It will not block myeloperoxidase release induced by IL-8. The antibody reacts with human CXCR-2 transfectant cells and not the parent cell line. The antibody shows no cross-reactivity with CXCR-1.
Inmunógeno
human CXCR2 transfected NSO mouse myeloma cells.
Acciones bioquímicas o fisiológicas
CXCR2 is a G protein-coupled receptor that binds IL-8 with high affinity. It mediates migration of neutrophils to the sites of inflammation. It also binds CXCL1 and stimulates growth of melanomas.
Forma física
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.
Nota de preparación
Purified using protein G.
Cláusula de descargo de responsabilidad
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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Snjezana Zaja-Milatovic et al.
Histology and histopathology, 23(11), 1399-1407 (2008-09-12)
Wound healing requires a complex series of reactions and interactions among cells and their mediators, resulting in an overlapping series of events including coagulation, inflammation, epithelialization, formation of granulation tissue, matrix and scar formation. Cytokines and chemokines promote inflammation, angiogenesis
Michael J Robertson
Journal of leukocyte biology, 71(2), 173-183 (2002-01-31)
Natural killer (NK) cells participate in innate and adaptive immune responses to obligate intracellular pathogens and malignant tumors. Two major NK cell subsets have been identified in humans: CD56(dim) CD16+ and CD56(bright) CD16-. Resting CD56(dim) CD16+ NK cells express CXCR1
Chia-Yuan Hsieh et al.
Journal of immunology (Baltimore, Md. : 1950), 193(7), 3693-3703 (2014-08-31)
IFN-γ mediates chemically induced skin inflammation; however, the mechanism by which IFN-γ-producing cells are recruited to the sites of inflammation remains undefined. Secretion of macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, from damaged cells may promote immune cell recruitment.
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