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Merck

B5645

Sigma-Aldrich

Anti-Bovine IgG (whole molecule) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

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About This Item

Número MDL:
Código UNSPSC:
12352203
NACRES:
NA.46

origen biológico

rabbit

Nivel de calidad

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

secondary antibodies

clon

polyclonal

Formulario

buffered aqueous solution

técnicas

indirect ELISA: 1:20,000

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

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Descripción general

IgG (immunoglobulin G) contributes to 10-20% of plasma protein and is regarded as one of the most predominant serum proteins. It consists of four subclasses: IgG1, IgG2, IgG3 and IgG4. The IgG structure possesses four polypeptide chains containing two identical γ heavy (H) chains and two identical κ or λ light (L) chains of 50 kDa and 25 kDa, respectively.
Immunoglobulin G (IgG) is the most important type of glycoprotein antibody present in human serum. It is found in blood and has four polypeptide chains.The light and heavy chains are interconnected by disulfide bonds. IgG has the longest serum half-life when compared to other immunoglobulins.

Aplicación

Anti-Bovine IgG (whole molecule) antibody produced in rabbit has been used to coat immulon 4HBX plates in serum antibody enzyme-linked immunosorbent assay (ELISA) and western blotting.
Anti-Bovine IgG (whole molecule) antibody produced in rabbit is suitable for ELISA at a working dilution of 1:20,000. It may be used for immunohistochemistry of formalin-fixed, paraffin-embedded sections at a dilution of 1:1000.

Acciones bioquímicas o fisiológicas

Immunoglobulin G (IgG) initiates the classical pathway of the complement system and also nullifies virus particles and toxins. Maternal IgG is transferred to the fetus through the placenta that is critical for the immune defense of the neonate against infections. IgG modulates antibody-dependent cell-mediated cytotoxicity (ADCC) and might be associated with allergy. Digestion of IgG by papain releases fragment antigen-binding (Fab) and pepsin digestion of IgG produces crystallizable (fc) fragment and a single dimeric F(ab)2. IgG levels in severe acute respiratory syndrome coronavirus (SARS-CoV)-2 infected patients may be used to evaluate the severity and prognosis of coronavirus disease 2019 (COVID-19).

Forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as preservative

Almacenamiento y estabilidad

For continuous use, store at 2-8 °C for up to one month. For extended storage, the solution may be frozen in working aliquots. Repeated freezing and thawing, or storage in "frost-free" freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

nwg

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Katrin Spiesberger et al.
PloS one, 10(10), e0140471-e0140471 (2015-10-16)
30 years ago, the potential of bispecific antibodies to engage cytotoxic T cells for the lysis of cancer cells was discovered. Today a variety of bispecific antibodies against diverse cell surface structures have been developed, the majority of them produced
B W Blais
Journal of food protection, 62(4), 386-389 (1999-07-27)
An enzyme immunoassay system based on the use of a macroporous swab as a solid phase for the capture and subsequent immunoenzymatic detection of immunoglobulin G (IgG) from meat residues on food contact surfaces was developed as a hygiene-monitoring tool.
Formalin-inactivated bovine RSV vaccine enhances a Th2 mediated immune response in infected cattle
Kalina WV, et al.
Vaccine, 22(11-12), 1465-1474 (2004)
Low expression of secreted frizzled-related protein 2 and nuclear accumulation of beta-catenin in aggressive nonfunctioning pituitary adenoma
Wu Y, et al.
Oncology Letters, 12(1), 199-206 (2016)
Transfer of maternal colostral leukocytes promotes development of the neonatal immune system: Part II. Effects on neonatal lymphocytes
Reber AJ, et al.
Veterinary Immunology and Immunopathology, 123(3-4), 305-313 (2008)

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