B2938

BEPP monohydrochloride

≥98% (HPLC)

• Sinónimos: 1H-Benzimidazole-1-ethanol, 2,3-dihydro-2-imino-alpha-(phenoxymethyl)-3-(phenylmethyl)- monohydrochloride
• Fórmula empírica (notación de Hill): C₂₃H₂₃N₃O₂ HCl
• Número de CAS: 455311-98-5
• Peso molecular: 409.91
• Número MDL: MFCD00964481
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329773209
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• condiciones de almacenamiento: desiccated
• color: white to off-white
• solubilidad: DMSO: >10 mg/mL
• temp. de almacenamiento: 2-8°C
• cadena SMILES: Cl.OC(COc1ccccc1)CN2C(=N)N(Cc3ccccc3)c4ccccc24
• InChI: 1S/C23H23N3O2.ClH/c24-23-25(15-18-9-3-1-4-10-18)21-13-7-8-14-22(21)26(23)16-19(27)17-28-20-11-5-2-6-12-20;/h1-14,19,24,27H,15-17H2;1H
• Clave InChI: KDMXJFUGIDGZQL-UHFFFAOYSA-N

Descripción

Acciones bioquímicas o fisiológicas

BEPP is a double-strand RNA-dependent protein kinase (PKR) activator.

BEPP is a double-strand RNA-dependent protein kinase (PKR) activator. The double-strand RNA (dsRNA)-dependent protein kinase is a ubiquitously expressed serine threonine kinase, inducible by interferon γ. PRK is involved in several curtail cellular regulations including phosphorylation of eIF2α (which leads to inhibition of protein synthesis and eliciting antivirus and antitumor activities), modulating activities of eIF2α, NF-κB, ATF-3, and p53. BEPP also inhibits the growth of a human lung cancer cell line overexpressing PKR.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable