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AV35903

Sigma-Aldrich

Anti-ETV7 antibody produced in rabbit

affinity isolated antibody

Sinónimos:

Anti-Ets variant gene 7 (TEL2 oncogene), Anti-TEL-2, Anti-TEL2, Anti-TELB

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

39 kDa

species reactivity

human

concentration

0.5 mg - 1 mg/mL

technique(s)

western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ETV7(51513)

Immunogen

Synthetic peptide directed towards the C terminal region of human ETV7

Biochem/physiol Actions

ETV7 belongs to the ETS family of transcription factors that are important in development, differentiation and oncogenesis. It is predominantly expressed in hematopoietic tissues and promotes lymphomagenesis along with Myc. ETV7 was reported to regulate red blood cell development in zebrafish via the cholesterol synthesis pathway.

Sequence

Synthetic peptide located within the following region: IIKKEPGQKLLFRFLKTPGKMVQDKHSHLEPLESQEQDRIEFKDKRPEIS

Physical form

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Zebrafish etv7 regulates red blood cell development through the cholesterol synthesis pathway.
Quintana AM, Picchione F, Klein Geltink RI, et al.
Disease models & mechanisms (2013)
Cintia Carella et al.
Blood, 107(3), 1124-1132 (2005-10-20)
TEL2/ETV7 is highly homologous to the ETS transcription factor TEL/ETV6, a frequent target of chromosome translocation in human leukemia. Although both proteins are transcriptional inhibitors binding similar DNA recognition sequences, they have opposite biologic effects: TEL inhibits proliferation while TEL2

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