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Merck

A8452

Sigma-Aldrich

Monoclonal Anti-α-Fetoprotein (AFP) antibody produced in mouse

ascites fluid, clone C3

Sinónimos:

Afp Antibody, Afp Antibody - Monoclonal Anti-α-Fetoprotein (AFP) antibody produced in mouse, Alpha Fetoprotein Antibody

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About This Item

Número MDL:
Código UNSPSC:
12352203
NACRES:
NA.46

origen biológico

mouse

Nivel de calidad

conjugado

unconjugated

forma del anticuerpo

ascites fluid

tipo de anticuerpo

primary antibodies

clon

C3, monoclonal

contiene

15 mM sodium azide

reactividad de especies

pig, canine, human

no debe reaccionar con

mouse, cat, rat, bovine

técnicas

dot blot: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:500 using human fetal liver
indirect ELISA: suitable

isotipo

IgG2a

Nº de acceso UniProt

Condiciones de envío

dry ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... AFP(174)

Descripción general

α-Fetoprotein (AFP) is a one of the main glycoprotein present in the fetal liver, gastrointestinal tract, and yolk sac. AFP levels in amniotic fluid have been used as biomarkers for anencephaly and spina bifida.
Monoclonal Anti-α-Fetoprotein (AFP) (mouse IgG2a isotype) is derived from the C3 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with purified human α-fetoprotein.

Inmunógeno

human α-fetoprotein

Aplicación

Monoclonal Anti-α-Fetoprotein (AFP) antibody produced in mouse has been used in:
  • enzyme-linked immunosorbent assay (ELISA)
  • dot blot
  • immunocytochemistry
  • immunofluorescence
  • immunocytochemistry

Mouse Monoclonal Anti-α-Fetoprotein has been used for immunocytochemistry. The product can also be used for dot blot and indirect ELISA.

Acciones bioquímicas o fisiológicas

Increased concentrations of α-fetoprotein (AFP) in serum are less common in patients with malignancies of the gastrointestinal tract and of other organ systems with massive hepatic metastases. Hence, AFP determination is useful for the diagnosis of certain germ line tumors that contain yolk sac structures (testicular and ovarian tumors), hepatocellular carcinoma (hepatoma), and some malignant tumors of the gastrointestinal tract. AFP serves as an important marker for certain genetic and embryonic defects. Routine screening of pregnancies with a risk of neural tube defects (spina bifida, anencephaly, and Down′s syndrome) may be facilitated by the monitoring of AFP levels.

Descripción de destino

AFP is a plasma protein found highly expressed in the human fetus where it functions to block the transport of estradiol across the placenta.

Forma física

The product is provided as ascites fluid with 0.1% sodium azide as a preservative.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Reduced PLP1 expression in induced pluripotent stem cells derived from a Pelizaeus-Merzbacher disease patient with a partial PLP1 duplication
Shimojima K, et al.
Journal of Human Genetics, 57(9), 580-580 (2012)
Alpha-fetoprotein in the antenatal diagnosis of anencephaly and spina bifida.
D J Brock et al.
Lancet (London, England), 2(7770), 197-199 (1972-07-29)
Alpha-fetoprotein in ontogenesis and its association with malignant tumors.
G I Abelev
Advances in cancer research, 14, 295-358 (1971-01-01)
Characterization of a novel embryonic stem cell line from an ICSI-derived blastocyst in the African green monkey
Shimozawa N, et al.
Reproduction (Cambridge, England), 139(3), 565-565 (2010)
Mark O Clements et al.
Tissue engineering, 12(7), 1741-1751 (2006-08-08)
Human stem cells could revolutionize the field of medicine by providing a diverse range of cell types for tissue replacement therapies and drug discovery. To achieve this goal, genetic tools need to be optimized and developed for controlling and manipulating

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