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Merck

45124

Sigma-Aldrich

Elastase from porcine pancreas

powder, white, ≥10 U/mg

Sinónimos:

Elastase from hog pancreas, Pancreatopeptidase E

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About This Item

Número de CAS:
Comisión internacional de enzimas:
EC Number:
MDL number:
UNSPSC Code:
12352204
NACRES:
NA.54

biological source

Porcine pancreas

form

powder

specific activity

≥10 U/mg

mol wt

Mr ~25000

color

white

storage temp.

−20°C

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Biochem/physiol Actions

Elastase hydrolyses elastin, the specific protein of elastic fibers, and digests hemoglobin, casein and fibrin.

Unit Definition

1 U corresponds to the amount of enzyme which liberates 1 μmol 4-nitroaniline per minute at 25°C and pH 7.8 (succinyl-(L-Ala)3-4-nitroanilide as substrate)
One unit will hydrolyze 1.0 μmole of N-succinyl-L-Ala-Ala-Ala-p-nitroanilide per min, pH 8.0 at 25 °C.

Other Notes

Cleaves polyalanyl-lysine peptides at the alanyl-lysine bond, review; Review, elastase-type proteases
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D. Atlas et al.
Proc. 13th Eur. Pept. Symp.: Peptides 1974, 361-361 (1975)
Huanlei Zhu et al.
International journal of clinical and experimental pathology, 12(4), 1260-1271 (2020-01-15)
The formation and rupture of aneurysms is a reversible process involving the destruction and repair of smooth muscle cells, and the proliferation of vascular smooth muscle cells (VSMC) and inflammation play an important role. In our study, we investigated whether
L Robert
Pathologie-biologie, 36(9), 1101-1107 (1988-11-01)
Elastin in the most resistant fibrous protein of the organisms. Its degradation is catalysed by proteases designated as elastases. Elastic fibers appeared during phylogenesis at the level of the first Vertebrates and rendered possible the emergence of efficient circulatory and
Hee-Jeong Choi et al.
Oxidative medicine and cellular longevity, 2020, 2905362-2905362 (2020-07-21)
Ultraviolet B (UVB) irradiation is major causative factor in skin aging. The aim of the present study was to investigate the protective effect of a 50% ethanol extract from Nypa fruticans (NF50E) against UVB-induced skin aging. The results indicated that
Barbara Spix et al.
Nature communications, 13(1), 318-318 (2022-01-16)
Lung emphysema and chronic bronchitis are the two most common causes of chronic obstructive pulmonary disease. Excess macrophage elastase MMP-12, which is predominantly secreted from alveolar macrophages, is known to mediate the development of lung injury and emphysema. Here, we

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