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315R-1

Sigma-Aldrich

PD-1 (EP239) Rabbit Monoclonal Primary Antibody

Sinónimos:

CD279, PD1, PDCD1, SLEB2, hPH-1, hSLE1, programmed cell death 1, programmed cell death protein 1, protein PD-1, systemic lupus erythematosus suseptibilitl 2

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

100
500

conjugado

unconjugated

forma del anticuerpo

culture supernatant

tipo de anticuerpo

primary antibodies

clon

EP239, monoclonal

descripción

For In Vitro Diagnostic Use in Select Regions (See Chart)

Formulario

buffered aqueous solution

reactividad de especies

human

envase

vial of 0.1 mL concentrate (315R-14)
vial of 0.1 mL concentrate Research Use Only (315R-14-RUO)
vial of 0.5 mL concentrate (315R-15)
vial of 1.0 mL concentrate (315R-16)
vial of 1.0 mL concentrate Research Use Only (315R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (315R-17-RUO)
vial of 1.0 mL predilute ready-to-use (315R-17)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (315R-18-RUO)
vial of 7.0 mL predilute ready-to-use (315R-18)

fabricante / nombre comercial

Cell Marque®

técnicas

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 (concentrated)

isotipo

IgG

control

lymph node, tonsil

Condiciones de envío

wet ice

temp. de almacenamiento

2-8°C

visualización

cytoplasmic, membranous

Información sobre el gen

human ... PDCD1(5133)

Descripción general

Programmed death-1 (PD-1) is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PD-1 is a marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and BCL6, PD-1 is expressed by few B-cells, so anti-PD-1 may be a more specific and useful marker in the identification of angioimmunoblastic lymphoma. In addition, PD-1 expression provides evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T-cells. PD-1 expression in angioimmunoblastic lymphoma lends further support to this model of T-cell oncogenesis, in which specific subtypes of T-cells may undergo neoplastic transformation and result in specific distinct histologic, immunophenotypic, and clinical subtypes of T-cell neoplasia.

Calidad

United States - IVD
Canada - IVD
European Union - IVD
Japan - RUO

Ligadura / enlace

PD-1 Positive Control Slides, Product No. 315S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forma física

Predilute: diluted in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide
Concentrate: diluted in Phosphate Buffered Saline, pH 7.2, with 1% BSA and <0.1% Sodium Azide

Nota de preparación

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Otras notas

For Technical Service please contact: 800-665-7284 or email: [email protected]

Información legal

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany

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Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


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Certificados de análisis (COA)

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Visite la Librería de documentos

Enhanced expression of programmed death-1 (PD-1)/PD-L1 in salivary glands of patients with Sjogren's syndrome.
Kobayashi M, Kawano S, Hatachi S, et al.
The Journal of Rheumatology, 32(11), 2156-2163 (2005)
Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer.
Hamanishi J, Mandai M, Iwasaki M, et al.
Proceedings of the National Academy of Sciences of the USA, 104(9), 3360-3365 (2007)
David M Dorfman et al.
The American journal of surgical pathology, 30(7), 802-810 (2006-07-05)
Programmed death-1 (PD-1), a member of the CD28 costimulatory receptor family, is expressed by germinal center-associated T cells in reactive lymphoid tissue. In a study of a wide range of lymphoproliferative disorders, neoplastic T cells in 23 cases of angioimmunoblastic
Jun Konishi et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 10(15), 5094-5100 (2004-08-07)
B7-H1/PD-L1 (B7-H1) and B7-DC/PD-L2 (B7-DC) are ligands for the receptor PD-1, which is known to negatively regulate T-cell activation. In the present study, we investigated the expression of B7-H1 and B7-DC in tumor specimens of non-small cell lung cancer and
Masaya Kobayashi et al.
The Journal of rheumatology, 32(11), 2156-2163 (2005-11-03)
Programmed death-1 (PD-1) mediates a negative signal and introduces tolerance for lymphocytes. Dysfunction of the PD-1 pathway is thought to result in autoimmune diseases such as rheumatoid arthritis (RA). To investigate the role of the PD-1/PD-L system in the pathology

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