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15721

Sigma-Aldrich

Polydatin

≥95% (HPLC)

Sinónimos:

Piceid, Reservatrol-3-β-mono-D-glucoside, Resveratrol 3-O-β-D-glucopyranoside

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About This Item

Fórmula empírica (notación de Hill):
C20H22O8
Número de CAS:
65914-17-2
Peso molecular:
390.38
Beilstein/REAXYS Number:
54837
UNSPSC Code:
12352201
PubChem Substance ID:
329750984
NACRES:
NA.25

Quality Level

100

assay

≥95% (HPLC)

form

powder

optical activity

[α]1/D -66.0±2.0° in ethanol

composition

carbon, 60.5-62.5%

storage temp.

2-8°C

SMILES string

OCC1O[C@@H](Oc2cc(O)cc(\C=C\c3ccc(O)cc3)c2)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C20H22O8/c21-10-16-17(24)18(25)19(26)20(28-16)27-15-8-12(7-14(23)9-15)2-1-11-3-5-13(22)6-4-11/h1-9,16-26H,10H2/b2-1+/t16?,17-,18+,19-,20-/m1/s1

InChI key

HSTZMXCBWJGKHG-AEGFYQLOSA-N

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Application

Polydatin, a type of polyphenolic phytoalexin, has many physiological and pharmacological effects including anti-inflammatory and anti-oxidative activities. Polydatin is an effective candidate drug for the protection of photo-inflammation. Polydatin exhibits therapeutic potential for vascular dementia, most likely due to its anti-oxidant activity and the direct protection of neurons.

Biochem/physiol Actions

Stilbene found in medicinal herbs. Antioxidant, anti-inflammatory and neuroprotective.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Jianxin Deng et al.
Journal of molecular and cellular cardiology, 53(5), 646-656 (2012-08-28)
Polydatin (PD), a resveratrol glucoside, has recently been suggested to have cardioprotective effects against heart diseases, including ischemia-reperfusion injury and pressure-overload induced ventricular remodeling. However, the mechanisms are poorly understood. This study aims to investigate the direct effects of PD
Hyunsu Park et al.
Journal of agricultural and food chemistry, 60(33), 8183-8189 (2012-07-25)
Piceid is widely used in food, cosmetics, and pharmaceuticals because of its therapeutic benefits. However, the use of piceid as a drug is limited because of its low solubility. To increase solubility, we synthesized piceid glucosides using maltosyltransferase from Caldicellulosiruptor
Jingming Zhang et al.
Molecular medicine reports, 6(4), 815-820 (2012-08-04)
The pathophysiology of non-alcoholic fatty liver disease remains incompletely elucidated, and available treatments are not entirely satisfactory. Polydatin, a stilbenoid compound derived from the rhizome of Polygonum cuspidatum, has been recognised to possess hepatoprotective and anti-inflammatory activities. The purpose of
Xiao-hui Li et al.
Mediators of inflammation, 2013, 354087-354087 (2013-02-23)
The present study was carried out to investigate the effects and mechanisms of polydatin (PD) in septic mice. The model of cecal ligation and puncture (CLP-)induced sepsis was employed. Pretreatment of mice with PD (15, 45, and 100 mg/kg) dose-dependently reduced
Run-Ping Li et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 19(8-9), 677-681 (2012-04-10)
Polydatin is one of the most common encountered stilbenes of nature and a key component of the Chinese herb Polygonum cuspidatum. This study is to investigate the effects of polydatin on learning and memory impairments induced by chronic cerebral hypoperfusion
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