The typical dosage of heparin for anticoagulation can vary based on the specific application and the type of blood product. For general anticoagulation, a common range is between 5 to 30 units of heparin per milliliter of blood. For cow's blood, the amount of this product needed will depend on the desired dosage and the volume of blood, which may be found in veterinary guidelines or literature. It is advisable to dissolve it in a saline solution or sterile water before use to ensure effective administration.
H3393
Heparina sodium salt from porcine intestinal mucosa
Grade I-A, ≥180 USP units/mg
Sinónimos:
Heparina de sodio
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About This Item
En este momento no podemos mostrarle ni los precios ni la disponibilidad
Productos recomendados
biological source
Porcine intestinal mucosa
Quality Level
type
Grade I-A
form
powder
specific activity
≥180 USP units/mg
color
beige
useful pH range
5.0 - 7.5
solubility
H2O: 50 mg/mL, clear, colorless to faintly yellow
application(s)
clinical research
diagnostic assay manufacturing
life science and biopharma
storage temp.
room temp
SMILES string
[Na+].[S](=O)(=O)(NC1C(OC(C(C1O[S](=O)(=O)O)OC4OC(C(C(C4O[S](=O)(=O)O)O)O)C(=O)O)CO)OC2C(OC(C(C2O)O[S](=O)(=O)O)OC3C(OC(C(C3O)NC(=O)C)O)CO[S](=O)(=O)O)C(=O)O)O
InChI key
JRTRSJGZMRQDHI-UHFFFAOYSA-N
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General description
La heparina es un glucosaminoglucano (GAG) perteneciente a la familia de los mucopolisacáridos, conocida por sus potentes propiedades anticoagulantes.[1] Este polisacárido muy sulfatado consiste en D-glucosamina y ácido hexurónico unidos mediante enlaces glucosídicos.[2] Encuentra una amplia aplicación en la investigación bioquímica y los estudios de cultivo celular.
Application
Se ha enriquecido la sal sódica de la heparina procedente de la mucosa intestinal porcina en el medio preparado para la inseminación de ovocitos con espermatozoides.[3][4] La sal sódica de heparina de la mucosa intestinal porcina se ha utilizado:
- para comprobar el efecto de la heparina en la comunicación del FGF21 (factor de crecimiento de fibroblastos 21).[5][5]
- en la inmunotinción de cortes cerebrales de ratón[6]
- para cuantificar los leucocitos y los eritrocitos de muestras de sangre de Sparus aurata[7]
- en la anticoagulación y el ensayo de inhibición del síndrome respiratorio agudo grave por coronavirus 2 (SARS-CoV2)[8]
Biochem/physiol Actions
La heparina es principalmente responsable del retraso en la coagulación de la sangre. Mejora la inactivación de las proteasas mediada por la antitrombina en la vía de la coagulación.[9]
La heparina se sintetiza en los mastocitos, igual que mediadores como la histamina, y se asocia con la alergia y la actividad inflamatoria.[10] La heparina demuestra efectos terapéuticos contra la trombosis venosa y la embolia pulmonar, ayuda a prevenir la retrombosis postrombólisis y permite el tratamiento de la trombosis arterial en pacientes con infarto agudo de miocardio. La heparina tiene acción antiinflamatoria en muchas afecciones inflamatorias como quemaduras, asma bronquial y colitis ulcerosa.[2]
La heparina se sintetiza en los mastocitos, igual que mediadores como la histamina, y se asocia con la alergia y la actividad inflamatoria.[10] La heparina demuestra efectos terapéuticos contra la trombosis venosa y la embolia pulmonar, ayuda a prevenir la retrombosis postrombólisis y permite el tratamiento de la trombosis arterial en pacientes con infarto agudo de miocardio. La heparina tiene acción antiinflamatoria en muchas afecciones inflamatorias como quemaduras, asma bronquial y colitis ulcerosa.[2]
Other Notes
Las disoluciones de heparina no deben ser esterilizadas en autoclave ya que puede producirse reticulación añadida de los azúcares a altas temperaturas. Tampoco debe congelarse.
Si desea conocer por completo nuestra amplia gama de polisacáridos para su investigación, le recomendamos que visite nuestra página de categoría Carbohidratos .
Si desea más información sobre nuestra gama de productos bioquímicos, cumplimente este formulario.
Recommended products
La heparina para diagnóstico está disponible con la referencia de producto SRE0027
Comparable product
Referencia del producto
Descripción
Precios
related product
Referencia del producto
Descripción
Precios
Storage Class
11 - Combustible Solids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Certificados de análisis (COA)
Lot/Batch Number
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Artículos
Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.
Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.
Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.
Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.
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How do I calculate how much Heparin sodium salt I need to prevent coagulation in a gallon of cow's blood? Would it have to be dissolved in a saline solution first?
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How can I determine the shelf life / expiration / retest date of this product?
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If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdfHelpful?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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please, could you explain me if this Heparin H3393 in one 'high molecolar wieght heparin'?
1 answer-
This product is a porcine heparin with a molecular weight range of 15-19 kDa. This material is considered a "high molecular weight heparin." According to the literature, low molecular weight heparins are those with a molecular weight of less than 8000 Da. See the link below to review a publication that may be helpful:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10141002/Helpful?
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How many grams of sodium heparin, derived from porcine intestinal mucosa, are contained in a single vial?
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This product is sold by units and vial content will vary from lot to lot. The minimum activity specification is 180 units/mg. The lot-specific activity is reported on the Certificate of Analysis. The following values indicate the least amounts will be present in each pack size:
10 KU: 56 mg
25 KU: 139 mg
50 KU: 278 mg
100 KU: 556 mg
250 KU: 1389 mg
500 KU: 2778 mg
1 MU: 5556 mgPlease see the link below to review a sample or lot specific Certificate:
https://www.sigmaaldrich.com/product/sial/h3393#product-documentationHelpful?
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What is the molecular weight of Heparin sodium salt?
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The molecular weight is determined in-house for the product. The correct molecular weight range for this product is 15-19kDa.
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How much Heparin sodium salt, is used to prevent coagulation?
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It is suggested to use 15 to 30 units per mL of blood.
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What is the Department of Transportation shipping information for this product?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What concentration of Heparin sodium salt, can I use to inhibit RNAse activity?
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Heparin has been used at concentrations ranging from 100 to 500 μg/mL. This has been reported in the J. Biol. Chem., 248, 2095 (1973).
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What is the best way to sterilize Heparin sodium salt?
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Although solutions may be autoclaved at 121 °C for 5 to 10 minutes, we generally recommend sterile filtration. This is because prolonged autoclaving may have an effect on its activity.
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