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Key Documents

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H102

Supelco

Haloperidol metabolite II

analytical standard

Sinónimos:

(±)-4-(4-Chlorophenyl)-α-(4-fluorophenyl)-4-hydroxy-1-piperidinebutanol, Reduced Haloperidol

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About This Item

Fórmula empírica (notación de Hill):
C21H25ClFNO2
Número de CAS:
34104-67-1
Peso molecular:
377.88
MDL number:
MFCD00055102
UNSPSC Code:
41116107
PubChem Substance ID:
329815151
NACRES:
NA.24

grade

analytical standard

Quality Level

100

assay

≥98% (HPLC)

form

solid

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

color

white

solubility

DMSO: 10 mg/mL

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

OC(CCCN1CCC(O)(CC1)c2ccc(Cl)cc2)c3ccc(F)cc3

InChI

1S/C21H25ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,20,25-26H,1-2,11-15H2

InChI key

WNZBBTJFOIOEMP-UHFFFAOYSA-N

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificados de análisis (COA)

Lot/Batch Number
0000361578
0000361578
FN09271904
027M4605V
078K4619

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J M Leroux et al.
Progress in neuro-psychopharmacology & biological psychiatry, 18(2), 347-353 (1994-03-01)
1. The authors attempted to correlate plasma concentrations in H/rH and clinical efficacy from 8 schizophrenic patients (DSM IIIR) on H. 2. No significant correlations were found between H, rH plasma levels and positive and negative subscale for each patient.
H Hoja et al.
Journal of chromatography. B, Biomedical sciences and applications, 688(2), 275-280 (1997-01-24)
A sensitive and accurate liquid chromatographic-electrospray mass spectrometric (LC-ES-MS) method for the determination of haloperidol (H) and reduced haloperidol (RH) in human plasma is presented, using chlorohaloperidol as the internal standard. A 2-ml volume of plasma was subjected to basic
S Ulrich et al.
International clinical psychopharmacology, 14(4), 219-228 (1999-09-01)
The aim of this study was to investigate the effect of reduced haloperidol, the main metabolite of the antipsychotic drug haloperidol, on psychopathology improvement and extrapyramidal adverse effects in acute schizophrenia. The steady-state pharmacokinetics of reduced haloperidol was studied. Serum
J G Shin et al.
British journal of clinical pharmacology, 51(1), 45-52 (2001-02-13)
We evaluated the inhibitory effect of haloperidol and its metabolites on CYP2D6 activity in order to better understand the potential role of these metabolites in drug interactions involving haloperidol. The inhibitory effects of haloperidol and five of its metabolites on
C J Van der Schyf et al.
Chemical research in toxicology, 7(3), 281-285 (1994-05-01)
The neuroleptic agent haloperidol (HP) is biotransformed in humans to a pyridinium metabolite, HPP+, that displays neurotoxic properties resembling those of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-derived neurotoxic pyridinium metabolite MPP+. We report here that HP and its tetrahydropyridine dehydration product 4-(4-chlorophenyl)-1-[4-(4-fluorophenyl)-4-oxobutyl]-1,2,3,6- tetrahydropyridine
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