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OP80

Sigma-Aldrich

Anti-APC (Ab-7) Mouse mAb (CC-1)

Sinónimos:

Anti-Adenomatus Polyposis Coli

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About This Item

Código UNSPSC:
12352203
NACRES:
NA.45

origen biológico

mouse

Nivel de calidad

100

clon

CC-1, monoclonal

Formulario

liquid

contiene

≤0.1% sodium azide

reactividad de especies

human, mouse, rat

fabricante / nombre comercial

Calbiochem®

condiciones de almacenamiento

do not freeze

técnicas

immunocytochemistry: suitable
immunofluorescence: suitable
immunohistochemistry (frozen sections): suitable

dilution

(Free-floating SectionsParaffin Sections)

isotipo

IgG2b

Condiciones de envío

wet ice

temp. de almacenamiento

2-8°C

Descripción general

Recognizes APC in oligodendrocytes and astrocytes.

  • Antibody Target Gene Symbol: APC
  • Target Synonym: AI047805, Apc7, AU020952, AW124434, BTPS2, DP2, DP2.5, DP3, Familial adenomatous polyposis, FAP, GS, Min, RATAPC
  • Entrez Gene Name: adenomatous polyposis coli
  • Hu Entrez ID: 324 (Related Antibodies: ST1150, OP62, OP47L, OP44)
  • Mu Entrez ID: 11789
  • RatEntrez ID: 24205

Inmunógeno

a recombinant protein consisting of amino acids 1-226 of APC

Aplicación

Frozen Sections (5 µg/ml) Immunofluorescence (5 µg/ml) Paraffin Sections (5 µg/ml, heat pre-treament required) Immunocytochemistry (see application references) Free Floating Sections (see application references)

Well suited for IHC and IF studies of oligodendrocytes and optic nerves due to the antibody′s staining of the cell body as opposed to the myelinated processes. Both frozen sections and formalin-fixed, paraffin-embedded brain sections can be used. Antibody should be titrated for optimal results in individual systems.

Envase

Please refer to vial label for lot-specific concentration

Advertencia

Toxicity: Standard Handling

Forma física

In 50 mM sodium phosphate buffer, 0.2% gelatin.

Nota de análisis

Negative control: MOPC 21 cells

Positive control: Purkinje cells or cerebellum tissue

Información legal

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Código de clase de almacenamiento

12 - Non Combustible Liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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J Groden et al.
Cell, 66(3), 589-600 (1991-08-09)
DNA from 61 unrelated patients with adenomatous polyposis coli (APC) was examined for mutations in three genes (DP1, SRP19, and DP2.5) located within a 100 kb region deleted in two of the patients. The intron-exon boundary sequences were defined for
L K Su et al.
Science (New York, N.Y.), 262(5140), 1734-1737 (1993-12-10)
Mutations of APC appear to initiate sporadic and inherited forms of human colorectal cancer. Although these mutations have been well characterized, little is known about the function of the APC gene product. Two cellular proteins that associate with APC were
The APC gene product in normal and tumor cells
Smith, K.J., et al.
Proceedings of the National Academy of Sciences, 90, 2846-2850 (1993)
K W Kinzler et al.
Science (New York, N.Y.), 251(4999), 1366-1370 (1991-03-15)
Recent studies have suggested the existence of a tumor suppressor gene located at chromosome region 5q21. DNA probes from this region were used to study a panel of sporadic colorectal carcinomas. One of these probes, cosmid 5.71, detected a somatically
R V Bhat et al.
Glia, 17(2), 169-174 (1996-06-01)
Mutations of the adenomatous polyposis coli (APC) tumor suppressor gene have been linked to familial polyposis, an inherited predisposition to colon cancer, and a high percentage of sporadic colon adenomas. Although this gene is best known for its role in
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