MABE897

Anti-ATRX Antibody

mouse monoclonal, 23C

• Sinónimos: ATRX, Transcriptional regulator ATRX, ATP-dependent helicase ATRX, X-linked helicase II, X-linked nuclear protein, XNP, Znf-HX
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• Nombre del producto: Anti-ATRX Antibody, clone 23C, clone 23C, from mouse
• origen biológico: mouse
• Nivel de calidad: 100
• forma del anticuerpo: purified antibody
• tipo de anticuerpo: primary antibodies
• clon: 23C, monoclonal
• reactividad de especies: mouse, human
• técnicas: immunocytochemistry: suitable; western blot: suitable
• isotipo: IgG1κ
• Nº de acceso NCBI: NP_000480
• Nº de acceso UniProt: P46100
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... ATRX(546)

Descripción

Descripción general

Transcriptional regulator ATRX (EC 3.6.4.12; UniProt P46100; also known as Alpha thalassemia/mental retardation syndrome X-linked, ATP-dependent helicase ATRX, DNA dependent ATPase and helicase, Helicase 2 X-linked, X-linked helicase II, X-linked nuclear protein, XNP, Zinc finger helicase, Znf-HX) is encoded by the PRF1 (Also known as ATR2, JMS, MRXHF1, RAD54, RAD54L, SFM1, SHS, XH2, XNP, ZNF-HX) gene in human (Gene ID 546). Rad54 belongs to the SWI/SNF family of chromatin remodeling proteins. Rad54 undergoes cell cycle-dependent phosphorylation, nuclear matrix and chromatin association, and is implicatetd in playing a role in gene regulation during interphase and mitosis. ATRX mutations are associated with an X-linked mental retardation (XLMR) syndrome. most often accompanied by alpha-thalassemia syndrome, as a result of diverse changes in DNA methylation.

Inmunógeno

Epitope: N-terminus

Recombinant protein corresponding to the N-terminus of human ATRX.

Aplicación

Anti-ATRX Antibody, clone 23C is an antibody against ATRX for use in Western Blotting and Immunocytochemistry.

Research Category
Epigenetics & Nuclear Function

Research Sub Category
Nuclear Receptors

Western Blotting Analysis: A representative lot detected ATRX in nuclear extracts from EBV-transformed lymphocytes (McDowell, T.L., et al. (1999). PNAS. 96(24):13983-13988).
Immunocytochemistry Analysis: A representative lot detected nuclear localization of ATRX in HeLa and L929 cells (McDowell, T.L., et al. (1999). PNAS. 96(24):13983-13988).

Calidad

Evaluated by Western Blotting in HeLa cell lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected ATRX in 10 µg of HeLa cell lysate.

Descripción de destino

~283 kDa observed

Forma física

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Otras notas

Concentration: Please refer to lot specific datasheet.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable